Cargando…

7T MRI Predicts Amelioration of Neurodegeneration in the Brain after AAV Gene Therapy

GM1 gangliosidosis (GM1) is a fatal neurodegenerative lysosomal storage disease that occurs most commonly in young children, with no effective treatment available. Long-term follow-up of GM1 cats treated by bilateral thalamic and deep cerebellar nuclei (DCN) injection of adeno-associated virus (AAV)...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gray-Edwards, Heather L., Maguire, Anne S., Salibi, Nouha, Ellis, Lauren E., Voss, Taylor L., Diffie, Elise B., Koehler, Jey, Randle, Ashley N., Taylor, Amanda R., Brunson, Brandon L., Denney, Thomas S., Beyers, Ronald J., Gentry, Atoska S., Gross, Amanda L., Batista, Ana R., Sena-Esteves, Miguel, Martin, Douglas R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society of Gene & Cell Therapy 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962699/ https://www.ncbi.nlm.nih.gov/pubmed/31970203 http://dx.doi.org/10.1016/j.omtm.2019.11.023

Ejemplares similares

Lipidomic Evaluation of Feline Neurologic Disease after AAV Gene Therapy
por: Gray-Edwards, Heather L., et al.
Publicado: (2017)

Characterization of Structural Connectivity of the Default Mode Network in Dogs using Diffusion Tensor Imaging
por: Robinson, Jennifer L., et al.
Publicado: (2016)

Zinc Nanoparticles Enhance Brain Connectivity in the Canine Olfactory Network: Evidence From an fMRI Study in Unrestrained Awake Dogs
por: Ramaihgari, Bhavitha, et al.
Publicado: (2018)

Functional MRI of the Olfactory System in Conscious Dogs
por: Jia, Hao, et al.
Publicado: (2014)

Clinical MR spectroscopy: first principles
por: Salibi, Nouha, et al.
Publicado: (1998)

Real-time MR tracking of AAV gene therapy with βgal-responsive MR probe in a murine model of GM1-gangliosidosis
por: Taghian, Toloo, et al.
Publicado: (2021)

AAV-Mediated Gene Delivery in a Feline Model of Sandhoff Disease Corrects Lysosomal Storage in the Central Nervous System
por: Rockwell, Hannah E., et al.
Publicado: (2015)

Selection of an Efficient AAV Vector for Robust CNS Transgene Expression
por: Hanlon, Killian S., et al.
Publicado: (2019)

AAV-Mediated CRISPR/Cas9 Gene Editing in Murine Phenylketonuria
por: Richards, Daelyn Y., et al.
Publicado: (2019)

Intracranial AAV‐IFN‐β gene therapy eliminates invasive xenograft glioblastoma and improves survival in orthotopic syngeneic murine model
por: GuhaSarkar, Dwijit, et al.
Publicado: (2017)

Deubiquitinases in Neurodegeneration
por: Bello, Abudu I., et al.
Publicado: (2022)

AAV-Mediated Gene Delivery in Adult GM1-Gangliosidosis Mice Corrects Lysosomal Storage in CNS and Improves Survival
por: Baek, Rena C., et al.
Publicado: (2010)

Long-Term Therapeutic Efficacy of Intravenous AAV-Mediated Hamartin Replacement in Mouse Model of Tuberous Sclerosis Type 1
por: Prabhakar, Shilpa, et al.
Publicado: (2019)

CRISPR/Cas9 as an antiviral against Orthopoxviruses using an AAV vector
por: Siegrist, Cathryn M., et al.
Publicado: (2020)

Human GLB1 knockout cerebral organoids: A model system for testing AAV9-mediated GLB1 gene therapy for reducing GM1 ganglioside storage in GM1 gangliosidosis
por: Latour, Yvonne L., et al.
Publicado: (2019)

AAV Recombineering with Single Strand Oligonucleotides
por: Hirsch, Matthew L., et al.
Publicado: (2009)

Innate Immune Responses to AAV Vectors
por: Rogers, Geoffrey L., et al.
Publicado: (2011)

Direct Interaction of Human Serum Proteins with AAV Virions to Enhance AAV Transduction: Immediate Impact on Clinical Applications
por: Wang, Mei, et al.
Publicado: (2016)

Differential Effects of AAV.BDNF and AAV.Ntf3 in the Deafened Adult Guinea Pig Ear
por: Budenz, Cameron L., et al.
Publicado: (2015)

Role of Microglia TLRs in Neurodegeneration
por: Fiebich, Bernd L., et al.
Publicado: (2018)

The Role of Bioenergetics in Neurodegeneration
por: Strope, Taylor A., et al.
Publicado: (2022)

Editorial: Advances in the Pathogenesis of Canine Neurologic Disease
por: Koehler, Jey W., et al.
Publicado: (2020)

AAV-8 and AAV-9 Vectors Cooperate with Serum Proteins Differently Than AAV-1 and AAV-6
por: Denard, Jérôme, et al.
Publicado: (2018)

AAVrh10 vector corrects pathology in animal models of GM1 gangliosidosis and achieves widespread distribution in the CNS of nonhuman primates
por: Hocquemiller, Michaël, et al.
Publicado: (2022)

Deciphering the role of tau in neurodegeneration using Adeno-Associated Viral (AAV) vectors to express human tau in the mouse forebrain
por: Lathuilière, Aurélien, et al.
Publicado: (2013)

Adeno-Associated Virus (AAV) as a Vector for Gene Therapy
por: Naso, Michael F., et al.
Publicado: (2017)

European Mistletoe (Viscum album) Extract Is Cytotoxic to Canine High-Grade Astrocytoma Cells In Vitro and Has Additive Effects with Mebendazole
por: Wright, Anna, et al.
Publicado: (2022)

Role of mitophagy in ocular neurodegeneration
por: Brooks, Calvin D., et al.
Publicado: (2023)

Breaking teleprinter ciphers at Bletchley Park: an edition of I.J. Good, D. Michie and G. Timms : general report on tunny with emphasis on statistical methods (1945)
por: Reeds, J, et al.
Publicado: (2015)

Near-perfect infectivity of wild-type AAV as benchmark for infectivity of recombinant AAV vectors
por: Zeltner, Nadja, et al.
Publicado: (2010)

AAV-Tau Mediates Pyramidal Neurodegeneration by Cell-Cycle Re-Entry without Neurofibrillary Tangle Formation in Wild-Type Mice
por: Jaworski, Tomasz, et al.
Publicado: (2009)

The unfolded protein response: mechanisms and therapy of neurodegeneration
por: Smith, Heather L., et al.
Publicado: (2016)

AAV-Mediated Gene Therapy for Choroideremia: Preclinical Studies in Personalized Models
por: Vasireddy, Vidyullatha, et al.
Publicado: (2013)

Novel Mutant AAV2 Rep Proteins Support AAV2 Replication without Blocking HSV-1 Helpervirus Replication
por: Seyffert, Michael, et al.
Publicado: (2017)

Separate Populations of Neurons in Ventral Striatum Encode Value and Motivation
por: Bissonette, Gregory B., et al.
Publicado: (2013)

Different definitions of neurodegeneration produce similar amyloid/neurodegeneration biomarker group findings
por: Jack, Clifford R., et al.
Publicado: (2015)

T Cell-Mediated Immune Responses to AAV and AAV Vectors
por: Ertl, Hildegund C. J.
Publicado: (2021)

Cell Signaling in Neurodegeneration
por: Zugaza, José L.
Publicado: (2021)

Adding recombinant AAVs to the cancer therapeutics mix
por: Mulcrone, Patrick L., et al.
Publicado: (2022)

Neurodegeneration, Neuroprotection and Regeneration in the Zebrafish Retina
por: Stella, Salvatore L., et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_codocio8pgn1s9elhg8rold2ga