Pathogenic Pathways in Early-Onset Autosomal Recessive Parkinson's Disease Discovered Using Isogenic Human Dopaminergic Neurons

Parkinson's disease (PD) is a complex and highly variable neurodegenerative disease. Familial PD is caused by mutations in several genes with diverse and mostly unknown functions. It is unclear how dysregulation of these genes results in the relatively selective death of nigral dopaminergic neu...

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Detalles Bibliográficos
Autores principales: Ahfeldt, Tim, Ordureau, Alban, Bell, Christina, Sarrafha, Lily, Sun, Chicheng, Piccinotti, Silvia, Grass, Tobias, Parfitt, Gustavo M., Paulo, Joao A., Yanagawa, Fumiki, Uozumi, Takayuki, Kiyota, Yasujiro, Harper, J. Wade, Rubin, Lee L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6962705/
https://www.ncbi.nlm.nih.gov/pubmed/31902706
http://dx.doi.org/10.1016/j.stemcr.2019.12.005

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