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The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans
Telomeres protect genomic integrity and shorten in somatic cells due to the end replication problem. Sperm telomeres are, however, longer in older individuals and linked to semen quality. Exercise training may attenuate age-related telomere shortening in somatic cells, but the influence of exercise...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Chang Gung University
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963005/ https://www.ncbi.nlm.nih.gov/pubmed/31948608 http://dx.doi.org/10.1016/j.bj.2019.07.003 |
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author | Denham, Joshua |
author_facet | Denham, Joshua |
author_sort | Denham, Joshua |
collection | PubMed |
description | Telomeres protect genomic integrity and shorten in somatic cells due to the end replication problem. Sperm telomeres are, however, longer in older individuals and linked to semen quality. Exercise training may attenuate age-related telomere shortening in somatic cells, but the influence of exercise on sperm telomeres is unknown. Mature sperm from 34 healthy men were isolated by density gradient centrifugation and telomere length was assessed by qPCR. No significant correlations were observed between telomere length, fitness or exercise performance. Inter-individual variation in sperm telomere length responses to a 6-wk vigorous exercise training intervention (ΔT/S ratio range: −0.49 to 0.87) and a strong correlation between improvements in fitness and sperm telomere lengthening were revealed (r = 0.87, p < 0.001). These preliminary data suggest exercise training may regulate sperm telomere length and should encourage larger studies to explore the implications this may have on the health of the next generation. |
format | Online Article Text |
id | pubmed-6963005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Chang Gung University |
record_format | MEDLINE/PubMed |
spelling | pubmed-69630052020-01-22 The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans Denham, Joshua Biomed J Short Communication Telomeres protect genomic integrity and shorten in somatic cells due to the end replication problem. Sperm telomeres are, however, longer in older individuals and linked to semen quality. Exercise training may attenuate age-related telomere shortening in somatic cells, but the influence of exercise on sperm telomeres is unknown. Mature sperm from 34 healthy men were isolated by density gradient centrifugation and telomere length was assessed by qPCR. No significant correlations were observed between telomere length, fitness or exercise performance. Inter-individual variation in sperm telomere length responses to a 6-wk vigorous exercise training intervention (ΔT/S ratio range: −0.49 to 0.87) and a strong correlation between improvements in fitness and sperm telomere lengthening were revealed (r = 0.87, p < 0.001). These preliminary data suggest exercise training may regulate sperm telomere length and should encourage larger studies to explore the implications this may have on the health of the next generation. Chang Gung University 2019-12 2019-12-26 /pmc/articles/PMC6963005/ /pubmed/31948608 http://dx.doi.org/10.1016/j.bj.2019.07.003 Text en © 2019 Chang Gung University. Publishing services by Elsevier B.V. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Short Communication Denham, Joshua The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans |
title | The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans |
title_full | The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans |
title_fullStr | The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans |
title_full_unstemmed | The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans |
title_short | The association between sperm telomere length, cardiorespiratory fitness and exercise training in humans |
title_sort | association between sperm telomere length, cardiorespiratory fitness and exercise training in humans |
topic | Short Communication |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963005/ https://www.ncbi.nlm.nih.gov/pubmed/31948608 http://dx.doi.org/10.1016/j.bj.2019.07.003 |
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