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The effect of antioxidant status on overall survival in renal cell carcinoma
INTRODUCTION: The oxidative stress contributes to all three phases of carcinogenesis and represents a concomitant condition in renal cell carcinoma (RCC). RCC is the most common type of neoplasm of the kidney, and despite numerous studies the set of predictive and prognostic markers of survival are...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Termedia Publishing House
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963148/ https://www.ncbi.nlm.nih.gov/pubmed/32051711 http://dx.doi.org/10.5114/aoms.2019.86818 |
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author | Pavlović, Ivan Pejić, Snežana Radojević-Škodrić, Sanja Todorović, Ana Stojiljković, Vesna Gavrilović, Ljubica Popović, Nataša Basta-Jovanović, Gordana Džamić, Zoran Pajović, Snežana B. |
author_facet | Pavlović, Ivan Pejić, Snežana Radojević-Škodrić, Sanja Todorović, Ana Stojiljković, Vesna Gavrilović, Ljubica Popović, Nataša Basta-Jovanović, Gordana Džamić, Zoran Pajović, Snežana B. |
author_sort | Pavlović, Ivan |
collection | PubMed |
description | INTRODUCTION: The oxidative stress contributes to all three phases of carcinogenesis and represents a concomitant condition in renal cell carcinoma (RCC). RCC is the most common type of neoplasm of the kidney, and despite numerous studies the set of predictive and prognostic markers of survival are still unknown. The aim of our study was to examine the relation between antioxidant (AO) status and overall survival (OS) in RCC patients. MATERIAL AND METHODS: Our study included 95 patients with RCC, who underwent radical nephrectomy. We analysed the prognostic role of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glutathione, and malondialdehyde) and other clinicopathological factors (size, grade, stage, and histological subtype) on the OS of RCC patients. RESULTS: The 5-year OS was 54.6%. The survival analysis related to AO parameters showed no significant difference in survival of RCC patients. The concentration of malondialdehyde, an indicator of lipid peroxidation, also had no significant effect on the survival rate of RCC patients. Univariate and multivariate analysis confirmed the significance of clinicopathological parameters (size, p < 0.001; Fuhrman grade, p = 0.001, and stage, p < 0.001) for patients’ survival. CONCLUSIONS: In our cohort of patients, different antioxidant parameters were not found to be predictors for OS of patients with RCC, who underwent radical nephrectomy. |
format | Online Article Text |
id | pubmed-6963148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Termedia Publishing House |
record_format | MEDLINE/PubMed |
spelling | pubmed-69631482020-02-12 The effect of antioxidant status on overall survival in renal cell carcinoma Pavlović, Ivan Pejić, Snežana Radojević-Škodrić, Sanja Todorović, Ana Stojiljković, Vesna Gavrilović, Ljubica Popović, Nataša Basta-Jovanović, Gordana Džamić, Zoran Pajović, Snežana B. Arch Med Sci Clinical Research INTRODUCTION: The oxidative stress contributes to all three phases of carcinogenesis and represents a concomitant condition in renal cell carcinoma (RCC). RCC is the most common type of neoplasm of the kidney, and despite numerous studies the set of predictive and prognostic markers of survival are still unknown. The aim of our study was to examine the relation between antioxidant (AO) status and overall survival (OS) in RCC patients. MATERIAL AND METHODS: Our study included 95 patients with RCC, who underwent radical nephrectomy. We analysed the prognostic role of antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase, glutathione S-transferase, glutathione reductase, glutathione, and malondialdehyde) and other clinicopathological factors (size, grade, stage, and histological subtype) on the OS of RCC patients. RESULTS: The 5-year OS was 54.6%. The survival analysis related to AO parameters showed no significant difference in survival of RCC patients. The concentration of malondialdehyde, an indicator of lipid peroxidation, also had no significant effect on the survival rate of RCC patients. Univariate and multivariate analysis confirmed the significance of clinicopathological parameters (size, p < 0.001; Fuhrman grade, p = 0.001, and stage, p < 0.001) for patients’ survival. CONCLUSIONS: In our cohort of patients, different antioxidant parameters were not found to be predictors for OS of patients with RCC, who underwent radical nephrectomy. Termedia Publishing House 2019-07-22 /pmc/articles/PMC6963148/ /pubmed/32051711 http://dx.doi.org/10.5114/aoms.2019.86818 Text en Copyright: © 2019 Termedia & Banach http://creativecommons.org/licenses/by-nc-sa/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0) License, allowing third parties to copy and redistribute the material in any medium or format and to remix, transform, and build upon the material, provided the original work is properly cited and states its license. |
spellingShingle | Clinical Research Pavlović, Ivan Pejić, Snežana Radojević-Škodrić, Sanja Todorović, Ana Stojiljković, Vesna Gavrilović, Ljubica Popović, Nataša Basta-Jovanović, Gordana Džamić, Zoran Pajović, Snežana B. The effect of antioxidant status on overall survival in renal cell carcinoma |
title | The effect of antioxidant status on overall survival in renal cell carcinoma |
title_full | The effect of antioxidant status on overall survival in renal cell carcinoma |
title_fullStr | The effect of antioxidant status on overall survival in renal cell carcinoma |
title_full_unstemmed | The effect of antioxidant status on overall survival in renal cell carcinoma |
title_short | The effect of antioxidant status on overall survival in renal cell carcinoma |
title_sort | effect of antioxidant status on overall survival in renal cell carcinoma |
topic | Clinical Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963148/ https://www.ncbi.nlm.nih.gov/pubmed/32051711 http://dx.doi.org/10.5114/aoms.2019.86818 |
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