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Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients

Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infecti...

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Autores principales: Rapone, Biagio, Converti, Ilaria, Santacroce, Luigi, Cesarano, Francesca, Vecchiet, Federico, Cacchio, Luciano, Scacco, Salvatore, Grassi, Roberta, Grassi, Felice Roberto, Gnoni, Antonio, Ferrara, Elisabetta, Nardi, Gianna Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963174/
https://www.ncbi.nlm.nih.gov/pubmed/31683838
http://dx.doi.org/10.3390/antibiotics8040209
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author Rapone, Biagio
Converti, Ilaria
Santacroce, Luigi
Cesarano, Francesca
Vecchiet, Federico
Cacchio, Luciano
Scacco, Salvatore
Grassi, Roberta
Grassi, Felice Roberto
Gnoni, Antonio
Ferrara, Elisabetta
Nardi, Gianna Maria
author_facet Rapone, Biagio
Converti, Ilaria
Santacroce, Luigi
Cesarano, Francesca
Vecchiet, Federico
Cacchio, Luciano
Scacco, Salvatore
Grassi, Roberta
Grassi, Felice Roberto
Gnoni, Antonio
Ferrara, Elisabetta
Nardi, Gianna Maria
author_sort Rapone, Biagio
collection PubMed
description Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infection-driven inflammation, often co-occurs in the in the hemodialysis population and correlates with markers of malnutrition and inflammation, such as albumin, creatinine, and C-reactive protein. Aim: The present study aimed to determine whether the periodontal inflammatory status parameters correlate with the albumin, creatinine, and C-reactive protein serum concentrations in HD patients, and investigate whether periodontal treatment improves these markers of nutritional and systemic inflammation. Materials and Methods: The serum creatinine, albumin, and C-reactive Protein (CRP) levels were measured at baseline and after non-surgical periodontal treatment, at 3 months and 6 months. Results: At 3 months, a significant correlation between plaque index and C-reactive protein (p = 0.012), bleeding on probing and C-reactive protein (p < 0.0019), and clinical attachment level and C-reactive protein (p = 0.022) was found. No significant correlation was found between clinical periodontal parameters and nutrition markers at each time. Conclusions: Our results confirmed the association between C-reactive protein serum concentration and periodontal inflammatory status, but further research is necessary to identify the contributing role of periodontitis on the onset and progression of MICS.
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spelling pubmed-69631742020-01-27 Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients Rapone, Biagio Converti, Ilaria Santacroce, Luigi Cesarano, Francesca Vecchiet, Federico Cacchio, Luciano Scacco, Salvatore Grassi, Roberta Grassi, Felice Roberto Gnoni, Antonio Ferrara, Elisabetta Nardi, Gianna Maria Antibiotics (Basel) Article Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infection-driven inflammation, often co-occurs in the in the hemodialysis population and correlates with markers of malnutrition and inflammation, such as albumin, creatinine, and C-reactive protein. Aim: The present study aimed to determine whether the periodontal inflammatory status parameters correlate with the albumin, creatinine, and C-reactive protein serum concentrations in HD patients, and investigate whether periodontal treatment improves these markers of nutritional and systemic inflammation. Materials and Methods: The serum creatinine, albumin, and C-reactive Protein (CRP) levels were measured at baseline and after non-surgical periodontal treatment, at 3 months and 6 months. Results: At 3 months, a significant correlation between plaque index and C-reactive protein (p = 0.012), bleeding on probing and C-reactive protein (p < 0.0019), and clinical attachment level and C-reactive protein (p = 0.022) was found. No significant correlation was found between clinical periodontal parameters and nutrition markers at each time. Conclusions: Our results confirmed the association between C-reactive protein serum concentration and periodontal inflammatory status, but further research is necessary to identify the contributing role of periodontitis on the onset and progression of MICS. MDPI 2019-11-01 /pmc/articles/PMC6963174/ /pubmed/31683838 http://dx.doi.org/10.3390/antibiotics8040209 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Rapone, Biagio
Converti, Ilaria
Santacroce, Luigi
Cesarano, Francesca
Vecchiet, Federico
Cacchio, Luciano
Scacco, Salvatore
Grassi, Roberta
Grassi, Felice Roberto
Gnoni, Antonio
Ferrara, Elisabetta
Nardi, Gianna Maria
Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients
title Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients
title_full Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients
title_fullStr Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients
title_full_unstemmed Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients
title_short Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients
title_sort impact of periodontal inflammation on nutrition and inflammation markers in hemodialysis patients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963174/
https://www.ncbi.nlm.nih.gov/pubmed/31683838
http://dx.doi.org/10.3390/antibiotics8040209
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