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Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients
Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infecti...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963174/ https://www.ncbi.nlm.nih.gov/pubmed/31683838 http://dx.doi.org/10.3390/antibiotics8040209 |
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author | Rapone, Biagio Converti, Ilaria Santacroce, Luigi Cesarano, Francesca Vecchiet, Federico Cacchio, Luciano Scacco, Salvatore Grassi, Roberta Grassi, Felice Roberto Gnoni, Antonio Ferrara, Elisabetta Nardi, Gianna Maria |
author_facet | Rapone, Biagio Converti, Ilaria Santacroce, Luigi Cesarano, Francesca Vecchiet, Federico Cacchio, Luciano Scacco, Salvatore Grassi, Roberta Grassi, Felice Roberto Gnoni, Antonio Ferrara, Elisabetta Nardi, Gianna Maria |
author_sort | Rapone, Biagio |
collection | PubMed |
description | Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infection-driven inflammation, often co-occurs in the in the hemodialysis population and correlates with markers of malnutrition and inflammation, such as albumin, creatinine, and C-reactive protein. Aim: The present study aimed to determine whether the periodontal inflammatory status parameters correlate with the albumin, creatinine, and C-reactive protein serum concentrations in HD patients, and investigate whether periodontal treatment improves these markers of nutritional and systemic inflammation. Materials and Methods: The serum creatinine, albumin, and C-reactive Protein (CRP) levels were measured at baseline and after non-surgical periodontal treatment, at 3 months and 6 months. Results: At 3 months, a significant correlation between plaque index and C-reactive protein (p = 0.012), bleeding on probing and C-reactive protein (p < 0.0019), and clinical attachment level and C-reactive protein (p = 0.022) was found. No significant correlation was found between clinical periodontal parameters and nutrition markers at each time. Conclusions: Our results confirmed the association between C-reactive protein serum concentration and periodontal inflammatory status, but further research is necessary to identify the contributing role of periodontitis on the onset and progression of MICS. |
format | Online Article Text |
id | pubmed-6963174 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69631742020-01-27 Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients Rapone, Biagio Converti, Ilaria Santacroce, Luigi Cesarano, Francesca Vecchiet, Federico Cacchio, Luciano Scacco, Salvatore Grassi, Roberta Grassi, Felice Roberto Gnoni, Antonio Ferrara, Elisabetta Nardi, Gianna Maria Antibiotics (Basel) Article Background: Malnutrition-inflammation complex syndrome (MICS) is a common and usually concurrent condition occurring in patients undergoing hemodialysis (HD), with a pathogenesis linked to biological and in situ environmental traditional risk factors. Periodontitis, one of the major types of infection-driven inflammation, often co-occurs in the in the hemodialysis population and correlates with markers of malnutrition and inflammation, such as albumin, creatinine, and C-reactive protein. Aim: The present study aimed to determine whether the periodontal inflammatory status parameters correlate with the albumin, creatinine, and C-reactive protein serum concentrations in HD patients, and investigate whether periodontal treatment improves these markers of nutritional and systemic inflammation. Materials and Methods: The serum creatinine, albumin, and C-reactive Protein (CRP) levels were measured at baseline and after non-surgical periodontal treatment, at 3 months and 6 months. Results: At 3 months, a significant correlation between plaque index and C-reactive protein (p = 0.012), bleeding on probing and C-reactive protein (p < 0.0019), and clinical attachment level and C-reactive protein (p = 0.022) was found. No significant correlation was found between clinical periodontal parameters and nutrition markers at each time. Conclusions: Our results confirmed the association between C-reactive protein serum concentration and periodontal inflammatory status, but further research is necessary to identify the contributing role of periodontitis on the onset and progression of MICS. MDPI 2019-11-01 /pmc/articles/PMC6963174/ /pubmed/31683838 http://dx.doi.org/10.3390/antibiotics8040209 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Rapone, Biagio Converti, Ilaria Santacroce, Luigi Cesarano, Francesca Vecchiet, Federico Cacchio, Luciano Scacco, Salvatore Grassi, Roberta Grassi, Felice Roberto Gnoni, Antonio Ferrara, Elisabetta Nardi, Gianna Maria Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients |
title | Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients |
title_full | Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients |
title_fullStr | Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients |
title_full_unstemmed | Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients |
title_short | Impact of Periodontal Inflammation on Nutrition and Inflammation Markers in Hemodialysis Patients |
title_sort | impact of periodontal inflammation on nutrition and inflammation markers in hemodialysis patients |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963174/ https://www.ncbi.nlm.nih.gov/pubmed/31683838 http://dx.doi.org/10.3390/antibiotics8040209 |
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