Cargando…

NF-κB and MicroRNA Deregulation Mediated by HTLV-1 Tax and HBZ

The risk of developing adult T-cell leukemia/lymphoma (ATLL) in individuals infected with human T-cell lymphotropic virus 1 (HTLV-1) is about 3–5%. The mechanisms by which the virus triggers this aggressive cancer are still an area of intensive investigation. The viral protein Tax-1, together with a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fochi, Stefania, Ciminale, Vincenzo, Trabetti, Elisabetta, Bertazzoni, Umberto, D’Agostino, Donna M., Zipeto, Donato, Romanelli, Maria Grazia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963194/ https://www.ncbi.nlm.nih.gov/pubmed/31835460 http://dx.doi.org/10.3390/pathogens8040290

Ejemplares similares

HTLV Deregulation of the NF-κB Pathway: An Update on Tax and Antisense Proteins Role
por: Fochi, Stefania, et al.
Publicado: (2018)

TRAF3 Is Required for NF-κB Pathway Activation Mediated by HTLV Tax Proteins
por: Fochi, Stefania, et al.
Publicado: (2019)

Highlights on distinctive structural and functional properties of HTLV Tax proteins
por: Romanelli, Maria Grazia, et al.
Publicado: (2013)

Editorial: Molecular Pathology of HTLV-1
por: Bertazzoni, Umberto, et al.
Publicado: (2018)

Ubiquitination and sumoylation of the HTLV-2 Tax-2B protein regulate its NF-κB activity: a comparative study with the HTLV-1 Tax-1 protein
por: Turci, Marco, et al.
Publicado: (2012)

HTLV-1 and HTLV-2: highly similar viruses with distinct oncogenic properties
por: Ciminale, Vincenzo, et al.
Publicado: (2014)

The Emerging Role of the RBM20 and PTBP1 Ribonucleoproteins in Heart Development and Cardiovascular Diseases
por: Fochi, Stefania, et al.
Publicado: (2020)

Comparison of the Genetic Organization, Expression Strategies and Oncogenic Potential of HTLV-1 and HTLV-2
por: Rende, Francesca, et al.
Publicado: (2012)

HTLV Tax-1 and Tax-2 proteins enhance interferon regulatory factor 3 dependent promoter activation
por: Diani, Erica, et al.
Publicado: (2014)

Role of HTLV-1 Tax and HBZ in the Pathogenesis of HAM/TSP
por: Enose-Akahata, Yoshimi, et al.
Publicado: (2017)

Intracellular Localization and Cellular Factors Interaction of HTLV-1 and HTLV-2 Tax Proteins: Similarities and Functional Differences
por: Bertazzoni, Umberto, et al.
Publicado: (2011)

Post-transcriptional Regulation of HTLV Gene Expression: Rex to the Rescue
por: D’Agostino, Donna M., et al.
Publicado: (2019)

HTLV-1-mediated dysregulation of the Wnt pathways: roles of Tax and HBZ
por: Ma, Guangyong, et al.
Publicado: (2014)

Expression of the HBZ and tax genes of HTLV-1in infective dermatitis associated with HTLV-I (IDH)
por: Batista, Everton S, et al.
Publicado: (2011)

Fine tuning of the temporal expression of HTLV-1 and HTLV-2
por: Cavallari, Ilaria, et al.
Publicado: (2013)

Molecular characterization of a Tax-2C protein variant identified in Brazilian subjects infected by HTLV-2C
por: Caterino-de-Araujo, Adele, et al.
Publicado: (2014)

Susceptibility of HBZ and Tax expressing primary HTLV-1+ T cell clones to CTL lysis
por: Rowan, Aileen G, et al.
Publicado: (2011)

Evaluation of the role of TAX, HBZ, and HTLV-1 proviral load on the survival of ATLL patients
por: Akbarin, Mohammad Mehdi, et al.
Publicado: (2017)

NF-κB Hyper-Activation by HTLV-1 Tax Induces Cellular Senescence, but Can Be Alleviated by the Viral Anti-Sense Protein HBZ
por: Zhi, Huijun, et al.
Publicado: (2011)

NF-κB hyper-activation by HTLV-1 Tax induces cellular senescence, but can be alleviated by the viral anti-sense protein HBZ
por: Zhi, Huijun, et al.
Publicado: (2011)

The HTLV-1 viral oncoproteins Tax and HBZ reprogram the cellular mRNA splicing landscape
por: Vandermeulen, Charlotte, et al.
Publicado: (2021)

HTLV-1 Infection and Adult T-Cell Leukemia/Lymphoma—A Tale of Two Proteins: Tax and HBZ
por: Giam, Chou-Zen, et al.
Publicado: (2016)

JunD/HBZ enhances HBZ enhances HTLV-1 antisense transcription
por: Peloponese, Jean-Marie, et al.
Publicado: (2011)

HBZ and its roles in HTLV-1 oncogenesis
por: Zhao, Tiejun, et al.
Publicado: (2012)

The Role of HBZ in HTLV-1-Induced Oncogenesis
por: Zhao, Tiejun
Publicado: (2016)

Opposite effect of Valproate on Tax and HBZ expression in T-lymphocytes from HTLV-1 asymptomatic carriers and HAM/TSP patients
por: Belrose, Gildas, et al.
Publicado: (2011)

HTLV-1 gene expression by individual infected clones determines susceptibility to lysis by cytotoxic T lymphocytes specific for Tax and HBZ
por: Rowan, Aileen G, et al.
Publicado: (2014)

Analysis of temporal expression of HTLV-2 reveals similarities and functional differences from HTLV-1
por: Bender, Cecilia, et al.
Publicado: (2011)

MiR-150 in HTLV-1 infection and T-cell transformation
por: D’Agostino, Donna M., et al.
Publicado: (2022)

Comparison of Tax-1 and Tax-2B post-translational modifications using specific lysine mutants in relation to activation of NF-κB and intracellular localization
por: Turci, Marco, et al.
Publicado: (2011)

Multifaceted functions and roles of HBZ in HTLV-1 pathogenesis
por: Ma, Guangyong, et al.
Publicado: (2016)

Comparative analysis of HTLV-1 and HTLV-2 post-translational modifications of Tax proteins in relation to their intracellular localization and activation of gene expression
por: Turci, Marco, et al.
Publicado: (2009)

HTLV-1 Hbz protein, but not hbz mRNA secondary structure, is critical for viral persistence and disease development
por: Maksimova, Victoria, et al.
Publicado: (2023)

The HBZ gene, a key player in HTLV-1 pathogenesis
por: Matsuoka, Masao, et al.
Publicado: (2009)

Identification and Characterization of HTLV-1 HBZ Post-Translational Modifications
por: Dissinger, Nathan, et al.
Publicado: (2014)

HBZ upregulates myoferlin expression to facilitate HTLV-1 infection
por: Polakowski, Nicholas, et al.
Publicado: (2023)

The HTLV-1 hbz antisense gene indirectly promotes tax expression via down-regulation of p30-II mRNA
por: Choudhary, Gunjan, et al.
Publicado: (2011)

The Expression of Tax and HBZ Genes in Serum-Derived Extracellular Vesicles From HTLV-1 Carriers Correlates to Proviral Load and Inflammatory Markers
por: de La-Roque, Debora Glenda Lima, et al.
Publicado: (2022)

Interplay between innate immunity and the viral oncoproteins Tax and HBZ in the pathogenesis and therapeutic response of HTLV-1 associated adult T cell leukemia
por: El Hajj, Hiba, et al.
Publicado: (2022)

Cytoplasmic and nuclear events controlling Tax-mediated activation of the NF-κB pathway: involvement of TAB2, IKKgamma/NEMO and calreticulin
por: Bex, Françoise, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_4cr81cqsdicpokb6bs41ucovc8