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Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections

Despite medical progress, more than a billion people still suffer daily from parasitic infections. Vaccination is recognized as one of the most sustainable options to control parasitic diseases. However, the development of protective and therapeutic vaccines against tropical parasites has proven to...

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Detalles Bibliográficos
Autores principales: Versteeg, Leroy, Almutairi, Mashal M., Hotez, Peter J., Pollet, Jeroen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963228/
https://www.ncbi.nlm.nih.gov/pubmed/31547081
http://dx.doi.org/10.3390/vaccines7040122
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author Versteeg, Leroy
Almutairi, Mashal M.
Hotez, Peter J.
Pollet, Jeroen
author_facet Versteeg, Leroy
Almutairi, Mashal M.
Hotez, Peter J.
Pollet, Jeroen
author_sort Versteeg, Leroy
collection PubMed
description Despite medical progress, more than a billion people still suffer daily from parasitic infections. Vaccination is recognized as one of the most sustainable options to control parasitic diseases. However, the development of protective and therapeutic vaccines against tropical parasites has proven to be exceptionally challenging for both scientific and economic reasons. For certain parasitic diseases, traditional vaccine platforms are not well-suited, due to the complexity of the parasite life cycles and the parasite’s ability to evade the human immune system. An effective anti-parasite vaccine platform needs to have the ability to develop and test novel candidate antigens fast and at high-throughput; it further needs to allow for multivalent combinations and must evoke a strong and well-defined immune response. Anti-parasitic vaccines need to be safe and economically attractive, especially in the world’s low- and middle-income countries. This review evaluates the potential of in vitro transcribed mRNA vaccines as a new class of preventive and therapeutic vaccine technologies for parasitic infections.
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spelling pubmed-69632282020-01-27 Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections Versteeg, Leroy Almutairi, Mashal M. Hotez, Peter J. Pollet, Jeroen Vaccines (Basel) Review Despite medical progress, more than a billion people still suffer daily from parasitic infections. Vaccination is recognized as one of the most sustainable options to control parasitic diseases. However, the development of protective and therapeutic vaccines against tropical parasites has proven to be exceptionally challenging for both scientific and economic reasons. For certain parasitic diseases, traditional vaccine platforms are not well-suited, due to the complexity of the parasite life cycles and the parasite’s ability to evade the human immune system. An effective anti-parasite vaccine platform needs to have the ability to develop and test novel candidate antigens fast and at high-throughput; it further needs to allow for multivalent combinations and must evoke a strong and well-defined immune response. Anti-parasitic vaccines need to be safe and economically attractive, especially in the world’s low- and middle-income countries. This review evaluates the potential of in vitro transcribed mRNA vaccines as a new class of preventive and therapeutic vaccine technologies for parasitic infections. MDPI 2019-09-20 /pmc/articles/PMC6963228/ /pubmed/31547081 http://dx.doi.org/10.3390/vaccines7040122 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Versteeg, Leroy
Almutairi, Mashal M.
Hotez, Peter J.
Pollet, Jeroen
Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections
title Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections
title_full Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections
title_fullStr Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections
title_full_unstemmed Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections
title_short Enlisting the mRNA Vaccine Platform to Combat Parasitic Infections
title_sort enlisting the mrna vaccine platform to combat parasitic infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963228/
https://www.ncbi.nlm.nih.gov/pubmed/31547081
http://dx.doi.org/10.3390/vaccines7040122
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