Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?

We report the first case, to our knowledge, in Italy, of a severe combined immunodeficiency patient with a persistent rotavirus infection due to a vaccine derived strain. Rotavirus was detected by enzyme immunoassays and RT-PCR in stool specimens for five months. The persistent infection was resolve...

Descripción completa

Detalles Bibliográficos
Autores principales: De Francesco, Maria Antonia, Ianiro, Giovanni, Monini, Marina, Vezzoli, Cesare, Schumacher, Richard Fabian, Giliani, Silvia, Lorenzin, Giovanni, Gurrieri, Francesca, Caruso, Arnaldo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963346/
https://www.ncbi.nlm.nih.gov/pubmed/31744133
http://dx.doi.org/10.3390/vaccines7040185
_version_ 1783488260218028032
author De Francesco, Maria Antonia
Ianiro, Giovanni
Monini, Marina
Vezzoli, Cesare
Schumacher, Richard Fabian
Giliani, Silvia
Lorenzin, Giovanni
Gurrieri, Francesca
Caruso, Arnaldo
author_facet De Francesco, Maria Antonia
Ianiro, Giovanni
Monini, Marina
Vezzoli, Cesare
Schumacher, Richard Fabian
Giliani, Silvia
Lorenzin, Giovanni
Gurrieri, Francesca
Caruso, Arnaldo
author_sort De Francesco, Maria Antonia
collection PubMed
description We report the first case, to our knowledge, in Italy, of a severe combined immunodeficiency patient with a persistent rotavirus infection due to a vaccine derived strain. Rotavirus was detected by enzyme immunoassays and RT-PCR in stool specimens for five months. The persistent infection was resolved after complete immune reconstitution achieved by hematopoietic stem cell transplantation. This case underlines the importance of neonatal SCID_screening.
format Online
Article
Text
id pubmed-6963346
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69633462020-02-26 Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face? De Francesco, Maria Antonia Ianiro, Giovanni Monini, Marina Vezzoli, Cesare Schumacher, Richard Fabian Giliani, Silvia Lorenzin, Giovanni Gurrieri, Francesca Caruso, Arnaldo Vaccines (Basel) Case Report We report the first case, to our knowledge, in Italy, of a severe combined immunodeficiency patient with a persistent rotavirus infection due to a vaccine derived strain. Rotavirus was detected by enzyme immunoassays and RT-PCR in stool specimens for five months. The persistent infection was resolved after complete immune reconstitution achieved by hematopoietic stem cell transplantation. This case underlines the importance of neonatal SCID_screening. MDPI 2019-11-16 /pmc/articles/PMC6963346/ /pubmed/31744133 http://dx.doi.org/10.3390/vaccines7040185 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
De Francesco, Maria Antonia
Ianiro, Giovanni
Monini, Marina
Vezzoli, Cesare
Schumacher, Richard Fabian
Giliani, Silvia
Lorenzin, Giovanni
Gurrieri, Francesca
Caruso, Arnaldo
Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?
title Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?
title_full Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?
title_fullStr Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?
title_full_unstemmed Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?
title_short Persistent Infection with Rotavirus Vaccine Strain in Severe Combined Immunodeficiency (SCID) Child: Is Rotavirus Vaccination in SCID Children a Janus Face?
title_sort persistent infection with rotavirus vaccine strain in severe combined immunodeficiency (scid) child: is rotavirus vaccination in scid children a janus face?
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963346/
https://www.ncbi.nlm.nih.gov/pubmed/31744133
http://dx.doi.org/10.3390/vaccines7040185
work_keys_str_mv AT defrancescomariaantonia persistentinfectionwithrotavirusvaccinestraininseverecombinedimmunodeficiencyscidchildisrotavirusvaccinationinscidchildrenajanusface
AT ianirogiovanni persistentinfectionwithrotavirusvaccinestraininseverecombinedimmunodeficiencyscidchildisrotavirusvaccinationinscidchildrenajanusface
AT moninimarina persistentinfectionwithrotavirusvaccinestraininseverecombinedimmunodeficiencyscidchildisrotavirusvaccinationinscidchildrenajanusface
AT vezzolicesare persistentinfectionwithrotavirusvaccinestraininseverecombinedimmunodeficiencyscidchildisrotavirusvaccinationinscidchildrenajanusface
AT schumacherrichardfabian persistentinfectionwithrotavirusvaccinestraininseverecombinedimmunodeficiencyscidchildisrotavirusvaccinationinscidchildrenajanusface
AT gilianisilvia persistentinfectionwithrotavirusvaccinestraininseverecombinedimmunodeficiencyscidchildisrotavirusvaccinationinscidchildrenajanusface
AT lorenzingiovanni persistentinfectionwithrotavirusvaccinestraininseverecombinedimmunodeficiencyscidchildisrotavirusvaccinationinscidchildrenajanusface
AT gurrierifrancesca persistentinfectionwithrotavirusvaccinestraininseverecombinedimmunodeficiencyscidchildisrotavirusvaccinationinscidchildrenajanusface
AT carusoarnaldo persistentinfectionwithrotavirusvaccinestraininseverecombinedimmunodeficiencyscidchildisrotavirusvaccinationinscidchildrenajanusface

Ejemplares similares