Cargando…
Mimicking Sub-Structures Self-Organization in Microtubules
Microtubules (MTs) are highly dynamic polymers distributed in the cytoplasm of a biological cell. Alpha and beta globular proteins constituting the heterodimer building blocks combine to form these tubules through polymerization, controlled by the concentration of Guanosine-triphosphate (GTPs) and o...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963431/ https://www.ncbi.nlm.nih.gov/pubmed/31635308 http://dx.doi.org/10.3390/biomimetics4040071 |
_version_ | 1783488277364342784 |
---|---|
author | O. V., Sanjay Sarma Palaparthi, Sruthi Pidaparti, Ramana |
author_facet | O. V., Sanjay Sarma Palaparthi, Sruthi Pidaparti, Ramana |
author_sort | O. V., Sanjay Sarma |
collection | PubMed |
description | Microtubules (MTs) are highly dynamic polymers distributed in the cytoplasm of a biological cell. Alpha and beta globular proteins constituting the heterodimer building blocks combine to form these tubules through polymerization, controlled by the concentration of Guanosine-triphosphate (GTPs) and other Microtubule Associated Proteins (MAPs). MTs play a crucial role in many intracellular processes, predominantly in mitosis, organelle transport and cell locomotion. Current research in this area is focused on understanding the exclusive behaviors of self-organization and their association with different MAPs through organized laboratory experiments. However, the intriguing intelligence behind these tiny machines resulting in complex self-organizing structures is mostly unexplored. In this study, we propose a novel swarm engineering framework in modeling rules for these systems, by combining the principles of design with swarm intelligence. The proposed framework was simulated on a game engine and these simulations demonstrated self-organization of rings and protofilaments in MTs. Analytics from these simulations assisted in understanding the influence of GTPs on protofilament formation. Also, results showed that the population density of GTPs rather than their bonding probabilities played a crucial role in polymerization in forming microtubule substructures. |
format | Online Article Text |
id | pubmed-6963431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69634312020-02-26 Mimicking Sub-Structures Self-Organization in Microtubules O. V., Sanjay Sarma Palaparthi, Sruthi Pidaparti, Ramana Biomimetics (Basel) Article Microtubules (MTs) are highly dynamic polymers distributed in the cytoplasm of a biological cell. Alpha and beta globular proteins constituting the heterodimer building blocks combine to form these tubules through polymerization, controlled by the concentration of Guanosine-triphosphate (GTPs) and other Microtubule Associated Proteins (MAPs). MTs play a crucial role in many intracellular processes, predominantly in mitosis, organelle transport and cell locomotion. Current research in this area is focused on understanding the exclusive behaviors of self-organization and their association with different MAPs through organized laboratory experiments. However, the intriguing intelligence behind these tiny machines resulting in complex self-organizing structures is mostly unexplored. In this study, we propose a novel swarm engineering framework in modeling rules for these systems, by combining the principles of design with swarm intelligence. The proposed framework was simulated on a game engine and these simulations demonstrated self-organization of rings and protofilaments in MTs. Analytics from these simulations assisted in understanding the influence of GTPs on protofilament formation. Also, results showed that the population density of GTPs rather than their bonding probabilities played a crucial role in polymerization in forming microtubule substructures. MDPI 2019-10-18 /pmc/articles/PMC6963431/ /pubmed/31635308 http://dx.doi.org/10.3390/biomimetics4040071 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article O. V., Sanjay Sarma Palaparthi, Sruthi Pidaparti, Ramana Mimicking Sub-Structures Self-Organization in Microtubules |
title | Mimicking Sub-Structures Self-Organization in Microtubules |
title_full | Mimicking Sub-Structures Self-Organization in Microtubules |
title_fullStr | Mimicking Sub-Structures Self-Organization in Microtubules |
title_full_unstemmed | Mimicking Sub-Structures Self-Organization in Microtubules |
title_short | Mimicking Sub-Structures Self-Organization in Microtubules |
title_sort | mimicking sub-structures self-organization in microtubules |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963431/ https://www.ncbi.nlm.nih.gov/pubmed/31635308 http://dx.doi.org/10.3390/biomimetics4040071 |
work_keys_str_mv | AT ovsanjaysarma mimickingsubstructuresselforganizationinmicrotubules AT palaparthisruthi mimickingsubstructuresselforganizationinmicrotubules AT pidapartiramana mimickingsubstructuresselforganizationinmicrotubules |