Cargando…

Mimicking Sub-Structures Self-Organization in Microtubules

Microtubules (MTs) are highly dynamic polymers distributed in the cytoplasm of a biological cell. Alpha and beta globular proteins constituting the heterodimer building blocks combine to form these tubules through polymerization, controlled by the concentration of Guanosine-triphosphate (GTPs) and o...

Descripción completa

Detalles Bibliográficos
Autores principales: O. V., Sanjay Sarma, Palaparthi, Sruthi, Pidaparti, Ramana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963431/
https://www.ncbi.nlm.nih.gov/pubmed/31635308
http://dx.doi.org/10.3390/biomimetics4040071
_version_ 1783488277364342784
author O. V., Sanjay Sarma
Palaparthi, Sruthi
Pidaparti, Ramana
author_facet O. V., Sanjay Sarma
Palaparthi, Sruthi
Pidaparti, Ramana
author_sort O. V., Sanjay Sarma
collection PubMed
description Microtubules (MTs) are highly dynamic polymers distributed in the cytoplasm of a biological cell. Alpha and beta globular proteins constituting the heterodimer building blocks combine to form these tubules through polymerization, controlled by the concentration of Guanosine-triphosphate (GTPs) and other Microtubule Associated Proteins (MAPs). MTs play a crucial role in many intracellular processes, predominantly in mitosis, organelle transport and cell locomotion. Current research in this area is focused on understanding the exclusive behaviors of self-organization and their association with different MAPs through organized laboratory experiments. However, the intriguing intelligence behind these tiny machines resulting in complex self-organizing structures is mostly unexplored. In this study, we propose a novel swarm engineering framework in modeling rules for these systems, by combining the principles of design with swarm intelligence. The proposed framework was simulated on a game engine and these simulations demonstrated self-organization of rings and protofilaments in MTs. Analytics from these simulations assisted in understanding the influence of GTPs on protofilament formation. Also, results showed that the population density of GTPs rather than their bonding probabilities played a crucial role in polymerization in forming microtubule substructures.
format Online
Article
Text
id pubmed-6963431
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69634312020-02-26 Mimicking Sub-Structures Self-Organization in Microtubules O. V., Sanjay Sarma Palaparthi, Sruthi Pidaparti, Ramana Biomimetics (Basel) Article Microtubules (MTs) are highly dynamic polymers distributed in the cytoplasm of a biological cell. Alpha and beta globular proteins constituting the heterodimer building blocks combine to form these tubules through polymerization, controlled by the concentration of Guanosine-triphosphate (GTPs) and other Microtubule Associated Proteins (MAPs). MTs play a crucial role in many intracellular processes, predominantly in mitosis, organelle transport and cell locomotion. Current research in this area is focused on understanding the exclusive behaviors of self-organization and their association with different MAPs through organized laboratory experiments. However, the intriguing intelligence behind these tiny machines resulting in complex self-organizing structures is mostly unexplored. In this study, we propose a novel swarm engineering framework in modeling rules for these systems, by combining the principles of design with swarm intelligence. The proposed framework was simulated on a game engine and these simulations demonstrated self-organization of rings and protofilaments in MTs. Analytics from these simulations assisted in understanding the influence of GTPs on protofilament formation. Also, results showed that the population density of GTPs rather than their bonding probabilities played a crucial role in polymerization in forming microtubule substructures. MDPI 2019-10-18 /pmc/articles/PMC6963431/ /pubmed/31635308 http://dx.doi.org/10.3390/biomimetics4040071 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
O. V., Sanjay Sarma
Palaparthi, Sruthi
Pidaparti, Ramana
Mimicking Sub-Structures Self-Organization in Microtubules
title Mimicking Sub-Structures Self-Organization in Microtubules
title_full Mimicking Sub-Structures Self-Organization in Microtubules
title_fullStr Mimicking Sub-Structures Self-Organization in Microtubules
title_full_unstemmed Mimicking Sub-Structures Self-Organization in Microtubules
title_short Mimicking Sub-Structures Self-Organization in Microtubules
title_sort mimicking sub-structures self-organization in microtubules
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963431/
https://www.ncbi.nlm.nih.gov/pubmed/31635308
http://dx.doi.org/10.3390/biomimetics4040071
work_keys_str_mv AT ovsanjaysarma mimickingsubstructuresselforganizationinmicrotubules
AT palaparthisruthi mimickingsubstructuresselforganizationinmicrotubules
AT pidapartiramana mimickingsubstructuresselforganizationinmicrotubules