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Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands
The National Immunization Program (NIP) on Bonaire, St. Eustatius and Saba (i.e., Caribbean Netherlands (CN)) includes the measles-mumps-rubella (MMR) vaccine since 1988/89. Seroepidemiological data is an important tool to evaluate the NIP, hence a cross-sectional representative population-based ser...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963433/ https://www.ncbi.nlm.nih.gov/pubmed/31581508 http://dx.doi.org/10.3390/vaccines7040137 |
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author | Vos, Regnerus A. Mollema, Liesbeth van Binnendijk, Rob Veldhuijzen, Irene K. Smits, Gaby Janga-Jansen, Alcira V.A. Baboe-Kalpoe, Sharda Hulshof, Koen van der Klis, Fiona R.M. de Melker, Hester E. |
author_facet | Vos, Regnerus A. Mollema, Liesbeth van Binnendijk, Rob Veldhuijzen, Irene K. Smits, Gaby Janga-Jansen, Alcira V.A. Baboe-Kalpoe, Sharda Hulshof, Koen van der Klis, Fiona R.M. de Melker, Hester E. |
author_sort | Vos, Regnerus A. |
collection | PubMed |
description | The National Immunization Program (NIP) on Bonaire, St. Eustatius and Saba (i.e., Caribbean Netherlands (CN)) includes the measles-mumps-rubella (MMR) vaccine since 1988/89. Seroepidemiological data is an important tool to evaluate the NIP, hence a cross-sectional representative population-based serosurveillance study was conducted for the first time in CN in mid-2017. Participants (n = 1829, aged 0–90 years) donated a blood sample and completed a health-related questionnaire. MMR-specific IgG antibodies were determined using a bead-based multiplex immunoassay and risk factors were analyzed using logistic regression models. Overall seroprevalence was high for measles (94%), but lower for mumps and rubella (both 85%). In NIP eligibles, including women of childbearing age, rubella seroprevalence (88%) exceeded the threshold for protection (85%); however, for measles (89%) this protective level (95%) was not met. MMR seropositivity was lowest in children who became CN resident at 11–17 years of age (especially for measles (72%)), mostly originating from Latin America and other non-Western countries. Interestingly, rubella seroprevalence was lowest in non-NIP eligible adults from Dutch overseas territories and Suriname (75%). Taken together, MMR immunity is generally good in CN, nonetheless some risk groups were identified. Additionally, we found evidence for a unique island epidemiology. In light of recent regional measles outbreaks, disease monitoring remains of utmost importance. |
format | Online Article Text |
id | pubmed-6963433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69634332020-02-26 Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands Vos, Regnerus A. Mollema, Liesbeth van Binnendijk, Rob Veldhuijzen, Irene K. Smits, Gaby Janga-Jansen, Alcira V.A. Baboe-Kalpoe, Sharda Hulshof, Koen van der Klis, Fiona R.M. de Melker, Hester E. Vaccines (Basel) Article The National Immunization Program (NIP) on Bonaire, St. Eustatius and Saba (i.e., Caribbean Netherlands (CN)) includes the measles-mumps-rubella (MMR) vaccine since 1988/89. Seroepidemiological data is an important tool to evaluate the NIP, hence a cross-sectional representative population-based serosurveillance study was conducted for the first time in CN in mid-2017. Participants (n = 1829, aged 0–90 years) donated a blood sample and completed a health-related questionnaire. MMR-specific IgG antibodies were determined using a bead-based multiplex immunoassay and risk factors were analyzed using logistic regression models. Overall seroprevalence was high for measles (94%), but lower for mumps and rubella (both 85%). In NIP eligibles, including women of childbearing age, rubella seroprevalence (88%) exceeded the threshold for protection (85%); however, for measles (89%) this protective level (95%) was not met. MMR seropositivity was lowest in children who became CN resident at 11–17 years of age (especially for measles (72%)), mostly originating from Latin America and other non-Western countries. Interestingly, rubella seroprevalence was lowest in non-NIP eligible adults from Dutch overseas territories and Suriname (75%). Taken together, MMR immunity is generally good in CN, nonetheless some risk groups were identified. Additionally, we found evidence for a unique island epidemiology. In light of recent regional measles outbreaks, disease monitoring remains of utmost importance. MDPI 2019-10-01 /pmc/articles/PMC6963433/ /pubmed/31581508 http://dx.doi.org/10.3390/vaccines7040137 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Vos, Regnerus A. Mollema, Liesbeth van Binnendijk, Rob Veldhuijzen, Irene K. Smits, Gaby Janga-Jansen, Alcira V.A. Baboe-Kalpoe, Sharda Hulshof, Koen van der Klis, Fiona R.M. de Melker, Hester E. Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands |
title | Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands |
title_full | Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands |
title_fullStr | Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands |
title_full_unstemmed | Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands |
title_short | Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands |
title_sort | seroepidemiology of measles, mumps and rubella on bonaire, st. eustatius and saba: the first population-based serosurveillance study in caribbean netherlands |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963433/ https://www.ncbi.nlm.nih.gov/pubmed/31581508 http://dx.doi.org/10.3390/vaccines7040137 |
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