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Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands

The National Immunization Program (NIP) on Bonaire, St. Eustatius and Saba (i.e., Caribbean Netherlands (CN)) includes the measles-mumps-rubella (MMR) vaccine since 1988/89. Seroepidemiological data is an important tool to evaluate the NIP, hence a cross-sectional representative population-based ser...

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Autores principales: Vos, Regnerus A., Mollema, Liesbeth, van Binnendijk, Rob, Veldhuijzen, Irene K., Smits, Gaby, Janga-Jansen, Alcira V.A., Baboe-Kalpoe, Sharda, Hulshof, Koen, van der Klis, Fiona R.M., de Melker, Hester E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963433/
https://www.ncbi.nlm.nih.gov/pubmed/31581508
http://dx.doi.org/10.3390/vaccines7040137
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author Vos, Regnerus A.
Mollema, Liesbeth
van Binnendijk, Rob
Veldhuijzen, Irene K.
Smits, Gaby
Janga-Jansen, Alcira V.A.
Baboe-Kalpoe, Sharda
Hulshof, Koen
van der Klis, Fiona R.M.
de Melker, Hester E.
author_facet Vos, Regnerus A.
Mollema, Liesbeth
van Binnendijk, Rob
Veldhuijzen, Irene K.
Smits, Gaby
Janga-Jansen, Alcira V.A.
Baboe-Kalpoe, Sharda
Hulshof, Koen
van der Klis, Fiona R.M.
de Melker, Hester E.
author_sort Vos, Regnerus A.
collection PubMed
description The National Immunization Program (NIP) on Bonaire, St. Eustatius and Saba (i.e., Caribbean Netherlands (CN)) includes the measles-mumps-rubella (MMR) vaccine since 1988/89. Seroepidemiological data is an important tool to evaluate the NIP, hence a cross-sectional representative population-based serosurveillance study was conducted for the first time in CN in mid-2017. Participants (n = 1829, aged 0–90 years) donated a blood sample and completed a health-related questionnaire. MMR-specific IgG antibodies were determined using a bead-based multiplex immunoassay and risk factors were analyzed using logistic regression models. Overall seroprevalence was high for measles (94%), but lower for mumps and rubella (both 85%). In NIP eligibles, including women of childbearing age, rubella seroprevalence (88%) exceeded the threshold for protection (85%); however, for measles (89%) this protective level (95%) was not met. MMR seropositivity was lowest in children who became CN resident at 11–17 years of age (especially for measles (72%)), mostly originating from Latin America and other non-Western countries. Interestingly, rubella seroprevalence was lowest in non-NIP eligible adults from Dutch overseas territories and Suriname (75%). Taken together, MMR immunity is generally good in CN, nonetheless some risk groups were identified. Additionally, we found evidence for a unique island epidemiology. In light of recent regional measles outbreaks, disease monitoring remains of utmost importance.
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spelling pubmed-69634332020-02-26 Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands Vos, Regnerus A. Mollema, Liesbeth van Binnendijk, Rob Veldhuijzen, Irene K. Smits, Gaby Janga-Jansen, Alcira V.A. Baboe-Kalpoe, Sharda Hulshof, Koen van der Klis, Fiona R.M. de Melker, Hester E. Vaccines (Basel) Article The National Immunization Program (NIP) on Bonaire, St. Eustatius and Saba (i.e., Caribbean Netherlands (CN)) includes the measles-mumps-rubella (MMR) vaccine since 1988/89. Seroepidemiological data is an important tool to evaluate the NIP, hence a cross-sectional representative population-based serosurveillance study was conducted for the first time in CN in mid-2017. Participants (n = 1829, aged 0–90 years) donated a blood sample and completed a health-related questionnaire. MMR-specific IgG antibodies were determined using a bead-based multiplex immunoassay and risk factors were analyzed using logistic regression models. Overall seroprevalence was high for measles (94%), but lower for mumps and rubella (both 85%). In NIP eligibles, including women of childbearing age, rubella seroprevalence (88%) exceeded the threshold for protection (85%); however, for measles (89%) this protective level (95%) was not met. MMR seropositivity was lowest in children who became CN resident at 11–17 years of age (especially for measles (72%)), mostly originating from Latin America and other non-Western countries. Interestingly, rubella seroprevalence was lowest in non-NIP eligible adults from Dutch overseas territories and Suriname (75%). Taken together, MMR immunity is generally good in CN, nonetheless some risk groups were identified. Additionally, we found evidence for a unique island epidemiology. In light of recent regional measles outbreaks, disease monitoring remains of utmost importance. MDPI 2019-10-01 /pmc/articles/PMC6963433/ /pubmed/31581508 http://dx.doi.org/10.3390/vaccines7040137 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Vos, Regnerus A.
Mollema, Liesbeth
van Binnendijk, Rob
Veldhuijzen, Irene K.
Smits, Gaby
Janga-Jansen, Alcira V.A.
Baboe-Kalpoe, Sharda
Hulshof, Koen
van der Klis, Fiona R.M.
de Melker, Hester E.
Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands
title Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands
title_full Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands
title_fullStr Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands
title_full_unstemmed Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands
title_short Seroepidemiology of Measles, Mumps and Rubella on Bonaire, St. Eustatius and Saba: The First Population-Based Serosurveillance Study in Caribbean Netherlands
title_sort seroepidemiology of measles, mumps and rubella on bonaire, st. eustatius and saba: the first population-based serosurveillance study in caribbean netherlands
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963433/
https://www.ncbi.nlm.nih.gov/pubmed/31581508
http://dx.doi.org/10.3390/vaccines7040137
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