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Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children
The effectiveness and impact of the 13-valent pneumococcal conjugate vaccine (PCV13) against invasive pneumococcal diseases (IPD) due to serotype 3 (ser3) has been questioned. However, the impact of PCV13 on different clinical presentations of ser3-IPD has not been studied so far. The impact of PCV1...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963450/ https://www.ncbi.nlm.nih.gov/pubmed/31554213 http://dx.doi.org/10.3390/vaccines7040128 |
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author | Lodi, Lorenzo Ricci, Silvia Nieddu, Francesco Moriondo, Maria Lippi, Francesca Canessa, Clementina Mangone, Giusi Cortimiglia, Martina Casini, Arianna Lucenteforte, Ersilia Indolfi, Giuseppe Resti, Massimo Azzari, Chiara |
author_facet | Lodi, Lorenzo Ricci, Silvia Nieddu, Francesco Moriondo, Maria Lippi, Francesca Canessa, Clementina Mangone, Giusi Cortimiglia, Martina Casini, Arianna Lucenteforte, Ersilia Indolfi, Giuseppe Resti, Massimo Azzari, Chiara |
author_sort | Lodi, Lorenzo |
collection | PubMed |
description | The effectiveness and impact of the 13-valent pneumococcal conjugate vaccine (PCV13) against invasive pneumococcal diseases (IPD) due to serotype 3 (ser3) has been questioned. However, the impact of PCV13 on different clinical presentations of ser3-IPD has not been studied so far. The impact of PCV13 on different clinical presentations of ser3-IPD in a population of Italian children aged 0–8 years was evaluated, comparing pre- and post-PCV13 introduction period. Real-time polymerase chain reaction (PCR) was used for the diagnosis and serotyping of IPD. During the observation period (1 January 2006–1 August 2018), ser3 was detected in 60/284 (21.1%) children under 8 with serotyped IPD. The incidence of sepsis and meningitis was 0.24 per 1,000,000 person-years (p-y) in pre-PCV13 and 0.02 per 1,000,000 p-y in post-PCV13. No cases occurred in vaccinated children. In the post-PCV13 period, case reduction was 13% for all ser3 IPD and 92% for sepsis and meningitis. Vaccination impact may be underestimated due to significant improvement in pneumococcal surveillance in post-PCVC13. Our data suggest a significant impact of PCV13 on meningitis and sepsis due to ser3 and a lower impact against pneumonia. While waiting for increasingly effective anti-pneumococcal vaccines, PCV13, which guarantees protection against the most severe clinical presentations of ser3-IPD, is currently the most effective prevention option available. |
format | Online Article Text |
id | pubmed-6963450 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69634502020-01-30 Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children Lodi, Lorenzo Ricci, Silvia Nieddu, Francesco Moriondo, Maria Lippi, Francesca Canessa, Clementina Mangone, Giusi Cortimiglia, Martina Casini, Arianna Lucenteforte, Ersilia Indolfi, Giuseppe Resti, Massimo Azzari, Chiara Vaccines (Basel) Article The effectiveness and impact of the 13-valent pneumococcal conjugate vaccine (PCV13) against invasive pneumococcal diseases (IPD) due to serotype 3 (ser3) has been questioned. However, the impact of PCV13 on different clinical presentations of ser3-IPD has not been studied so far. The impact of PCV13 on different clinical presentations of ser3-IPD in a population of Italian children aged 0–8 years was evaluated, comparing pre- and post-PCV13 introduction period. Real-time polymerase chain reaction (PCR) was used for the diagnosis and serotyping of IPD. During the observation period (1 January 2006–1 August 2018), ser3 was detected in 60/284 (21.1%) children under 8 with serotyped IPD. The incidence of sepsis and meningitis was 0.24 per 1,000,000 person-years (p-y) in pre-PCV13 and 0.02 per 1,000,000 p-y in post-PCV13. No cases occurred in vaccinated children. In the post-PCV13 period, case reduction was 13% for all ser3 IPD and 92% for sepsis and meningitis. Vaccination impact may be underestimated due to significant improvement in pneumococcal surveillance in post-PCVC13. Our data suggest a significant impact of PCV13 on meningitis and sepsis due to ser3 and a lower impact against pneumonia. While waiting for increasingly effective anti-pneumococcal vaccines, PCV13, which guarantees protection against the most severe clinical presentations of ser3-IPD, is currently the most effective prevention option available. MDPI 2019-09-24 /pmc/articles/PMC6963450/ /pubmed/31554213 http://dx.doi.org/10.3390/vaccines7040128 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lodi, Lorenzo Ricci, Silvia Nieddu, Francesco Moriondo, Maria Lippi, Francesca Canessa, Clementina Mangone, Giusi Cortimiglia, Martina Casini, Arianna Lucenteforte, Ersilia Indolfi, Giuseppe Resti, Massimo Azzari, Chiara Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children |
title | Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children |
title_full | Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children |
title_fullStr | Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children |
title_full_unstemmed | Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children |
title_short | Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children |
title_sort | impact of the 13-valent pneumococcal conjugate vaccine on severe invasive disease caused by serotype 3 streptococcus pneumoniae in italian children |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963450/ https://www.ncbi.nlm.nih.gov/pubmed/31554213 http://dx.doi.org/10.3390/vaccines7040128 |
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