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Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children

The effectiveness and impact of the 13-valent pneumococcal conjugate vaccine (PCV13) against invasive pneumococcal diseases (IPD) due to serotype 3 (ser3) has been questioned. However, the impact of PCV13 on different clinical presentations of ser3-IPD has not been studied so far. The impact of PCV1...

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Autores principales: Lodi, Lorenzo, Ricci, Silvia, Nieddu, Francesco, Moriondo, Maria, Lippi, Francesca, Canessa, Clementina, Mangone, Giusi, Cortimiglia, Martina, Casini, Arianna, Lucenteforte, Ersilia, Indolfi, Giuseppe, Resti, Massimo, Azzari, Chiara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963450/
https://www.ncbi.nlm.nih.gov/pubmed/31554213
http://dx.doi.org/10.3390/vaccines7040128
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author Lodi, Lorenzo
Ricci, Silvia
Nieddu, Francesco
Moriondo, Maria
Lippi, Francesca
Canessa, Clementina
Mangone, Giusi
Cortimiglia, Martina
Casini, Arianna
Lucenteforte, Ersilia
Indolfi, Giuseppe
Resti, Massimo
Azzari, Chiara
author_facet Lodi, Lorenzo
Ricci, Silvia
Nieddu, Francesco
Moriondo, Maria
Lippi, Francesca
Canessa, Clementina
Mangone, Giusi
Cortimiglia, Martina
Casini, Arianna
Lucenteforte, Ersilia
Indolfi, Giuseppe
Resti, Massimo
Azzari, Chiara
author_sort Lodi, Lorenzo
collection PubMed
description The effectiveness and impact of the 13-valent pneumococcal conjugate vaccine (PCV13) against invasive pneumococcal diseases (IPD) due to serotype 3 (ser3) has been questioned. However, the impact of PCV13 on different clinical presentations of ser3-IPD has not been studied so far. The impact of PCV13 on different clinical presentations of ser3-IPD in a population of Italian children aged 0–8 years was evaluated, comparing pre- and post-PCV13 introduction period. Real-time polymerase chain reaction (PCR) was used for the diagnosis and serotyping of IPD. During the observation period (1 January 2006–1 August 2018), ser3 was detected in 60/284 (21.1%) children under 8 with serotyped IPD. The incidence of sepsis and meningitis was 0.24 per 1,000,000 person-years (p-y) in pre-PCV13 and 0.02 per 1,000,000 p-y in post-PCV13. No cases occurred in vaccinated children. In the post-PCV13 period, case reduction was 13% for all ser3 IPD and 92% for sepsis and meningitis. Vaccination impact may be underestimated due to significant improvement in pneumococcal surveillance in post-PCVC13. Our data suggest a significant impact of PCV13 on meningitis and sepsis due to ser3 and a lower impact against pneumonia. While waiting for increasingly effective anti-pneumococcal vaccines, PCV13, which guarantees protection against the most severe clinical presentations of ser3-IPD, is currently the most effective prevention option available.
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spelling pubmed-69634502020-01-30 Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children Lodi, Lorenzo Ricci, Silvia Nieddu, Francesco Moriondo, Maria Lippi, Francesca Canessa, Clementina Mangone, Giusi Cortimiglia, Martina Casini, Arianna Lucenteforte, Ersilia Indolfi, Giuseppe Resti, Massimo Azzari, Chiara Vaccines (Basel) Article The effectiveness and impact of the 13-valent pneumococcal conjugate vaccine (PCV13) against invasive pneumococcal diseases (IPD) due to serotype 3 (ser3) has been questioned. However, the impact of PCV13 on different clinical presentations of ser3-IPD has not been studied so far. The impact of PCV13 on different clinical presentations of ser3-IPD in a population of Italian children aged 0–8 years was evaluated, comparing pre- and post-PCV13 introduction period. Real-time polymerase chain reaction (PCR) was used for the diagnosis and serotyping of IPD. During the observation period (1 January 2006–1 August 2018), ser3 was detected in 60/284 (21.1%) children under 8 with serotyped IPD. The incidence of sepsis and meningitis was 0.24 per 1,000,000 person-years (p-y) in pre-PCV13 and 0.02 per 1,000,000 p-y in post-PCV13. No cases occurred in vaccinated children. In the post-PCV13 period, case reduction was 13% for all ser3 IPD and 92% for sepsis and meningitis. Vaccination impact may be underestimated due to significant improvement in pneumococcal surveillance in post-PCVC13. Our data suggest a significant impact of PCV13 on meningitis and sepsis due to ser3 and a lower impact against pneumonia. While waiting for increasingly effective anti-pneumococcal vaccines, PCV13, which guarantees protection against the most severe clinical presentations of ser3-IPD, is currently the most effective prevention option available. MDPI 2019-09-24 /pmc/articles/PMC6963450/ /pubmed/31554213 http://dx.doi.org/10.3390/vaccines7040128 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lodi, Lorenzo
Ricci, Silvia
Nieddu, Francesco
Moriondo, Maria
Lippi, Francesca
Canessa, Clementina
Mangone, Giusi
Cortimiglia, Martina
Casini, Arianna
Lucenteforte, Ersilia
Indolfi, Giuseppe
Resti, Massimo
Azzari, Chiara
Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children
title Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children
title_full Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children
title_fullStr Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children
title_full_unstemmed Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children
title_short Impact of the 13-Valent Pneumococcal Conjugate Vaccine on Severe Invasive Disease Caused by Serotype 3 Streptococcus Pneumoniae in Italian Children
title_sort impact of the 13-valent pneumococcal conjugate vaccine on severe invasive disease caused by serotype 3 streptococcus pneumoniae in italian children
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963450/
https://www.ncbi.nlm.nih.gov/pubmed/31554213
http://dx.doi.org/10.3390/vaccines7040128
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