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Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs
Epilepsy is a central neurological disorder affecting individuals of all ages and causing unpredictable seizures. In spite of the improved efficacy of new antiepileptic drugs and novel therapy, there are still approximately 20%~30% of patients, who have either intractable or uncontrolled seizures. T...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963462/ https://www.ncbi.nlm.nih.gov/pubmed/31801232 http://dx.doi.org/10.3390/diagnostics9040208 |
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author | Ko, Younhee Lee, Chulho Lee, Youngmok Lee, Jin-Sung |
author_facet | Ko, Younhee Lee, Chulho Lee, Youngmok Lee, Jin-Sung |
author_sort | Ko, Younhee |
collection | PubMed |
description | Epilepsy is a central neurological disorder affecting individuals of all ages and causing unpredictable seizures. In spite of the improved efficacy of new antiepileptic drugs and novel therapy, there are still approximately 20%~30% of patients, who have either intractable or uncontrolled seizures. The epilepsy drug–target network (EDT) is constructed and successfully demonstrates the characteristics and efficacy of popularly used AEDs through the identification of causative genes for 60 epilepsy patients. We discovered that the causative genes of most intractable patients were not the targets of existing AEDs, as well as being very far from the etiological mechanisms of existing AEDs in the functional networks. We show that the existence of new drugs that target the causative genes of intractable epilepsy patients, which will be potential candidates for refractory epilepsy patients. Our systematic approach demonstrates a new possibility for drug repositioning through the combination of the drug-target and functional networks. |
format | Online Article Text |
id | pubmed-6963462 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69634622020-01-30 Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs Ko, Younhee Lee, Chulho Lee, Youngmok Lee, Jin-Sung Diagnostics (Basel) Article Epilepsy is a central neurological disorder affecting individuals of all ages and causing unpredictable seizures. In spite of the improved efficacy of new antiepileptic drugs and novel therapy, there are still approximately 20%~30% of patients, who have either intractable or uncontrolled seizures. The epilepsy drug–target network (EDT) is constructed and successfully demonstrates the characteristics and efficacy of popularly used AEDs through the identification of causative genes for 60 epilepsy patients. We discovered that the causative genes of most intractable patients were not the targets of existing AEDs, as well as being very far from the etiological mechanisms of existing AEDs in the functional networks. We show that the existence of new drugs that target the causative genes of intractable epilepsy patients, which will be potential candidates for refractory epilepsy patients. Our systematic approach demonstrates a new possibility for drug repositioning through the combination of the drug-target and functional networks. MDPI 2019-11-30 /pmc/articles/PMC6963462/ /pubmed/31801232 http://dx.doi.org/10.3390/diagnostics9040208 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ko, Younhee Lee, Chulho Lee, Youngmok Lee, Jin-Sung Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs |
title | Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs |
title_full | Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs |
title_fullStr | Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs |
title_full_unstemmed | Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs |
title_short | Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs |
title_sort | systematic approach for drug repositioning of anti-epileptic drugs |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963462/ https://www.ncbi.nlm.nih.gov/pubmed/31801232 http://dx.doi.org/10.3390/diagnostics9040208 |
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