Cargando…

Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs

Epilepsy is a central neurological disorder affecting individuals of all ages and causing unpredictable seizures. In spite of the improved efficacy of new antiepileptic drugs and novel therapy, there are still approximately 20%~30% of patients, who have either intractable or uncontrolled seizures. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Ko, Younhee, Lee, Chulho, Lee, Youngmok, Lee, Jin-Sung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963462/
https://www.ncbi.nlm.nih.gov/pubmed/31801232
http://dx.doi.org/10.3390/diagnostics9040208
_version_ 1783488284817620992
author Ko, Younhee
Lee, Chulho
Lee, Youngmok
Lee, Jin-Sung
author_facet Ko, Younhee
Lee, Chulho
Lee, Youngmok
Lee, Jin-Sung
author_sort Ko, Younhee
collection PubMed
description Epilepsy is a central neurological disorder affecting individuals of all ages and causing unpredictable seizures. In spite of the improved efficacy of new antiepileptic drugs and novel therapy, there are still approximately 20%~30% of patients, who have either intractable or uncontrolled seizures. The epilepsy drug–target network (EDT) is constructed and successfully demonstrates the characteristics and efficacy of popularly used AEDs through the identification of causative genes for 60 epilepsy patients. We discovered that the causative genes of most intractable patients were not the targets of existing AEDs, as well as being very far from the etiological mechanisms of existing AEDs in the functional networks. We show that the existence of new drugs that target the causative genes of intractable epilepsy patients, which will be potential candidates for refractory epilepsy patients. Our systematic approach demonstrates a new possibility for drug repositioning through the combination of the drug-target and functional networks.
format Online
Article
Text
id pubmed-6963462
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-69634622020-01-30 Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs Ko, Younhee Lee, Chulho Lee, Youngmok Lee, Jin-Sung Diagnostics (Basel) Article Epilepsy is a central neurological disorder affecting individuals of all ages and causing unpredictable seizures. In spite of the improved efficacy of new antiepileptic drugs and novel therapy, there are still approximately 20%~30% of patients, who have either intractable or uncontrolled seizures. The epilepsy drug–target network (EDT) is constructed and successfully demonstrates the characteristics and efficacy of popularly used AEDs through the identification of causative genes for 60 epilepsy patients. We discovered that the causative genes of most intractable patients were not the targets of existing AEDs, as well as being very far from the etiological mechanisms of existing AEDs in the functional networks. We show that the existence of new drugs that target the causative genes of intractable epilepsy patients, which will be potential candidates for refractory epilepsy patients. Our systematic approach demonstrates a new possibility for drug repositioning through the combination of the drug-target and functional networks. MDPI 2019-11-30 /pmc/articles/PMC6963462/ /pubmed/31801232 http://dx.doi.org/10.3390/diagnostics9040208 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ko, Younhee
Lee, Chulho
Lee, Youngmok
Lee, Jin-Sung
Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs
title Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs
title_full Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs
title_fullStr Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs
title_full_unstemmed Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs
title_short Systematic Approach for Drug Repositioning of Anti-Epileptic Drugs
title_sort systematic approach for drug repositioning of anti-epileptic drugs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963462/
https://www.ncbi.nlm.nih.gov/pubmed/31801232
http://dx.doi.org/10.3390/diagnostics9040208
work_keys_str_mv AT koyounhee systematicapproachfordrugrepositioningofantiepilepticdrugs
AT leechulho systematicapproachfordrugrepositioningofantiepilepticdrugs
AT leeyoungmok systematicapproachfordrugrepositioningofantiepilepticdrugs
AT leejinsung systematicapproachfordrugrepositioningofantiepilepticdrugs