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Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention
Over three billion are at risk of dengue infection with more than 100 million a year presenting with symptoms that can lead to deadly haemorrhagic disease. There are however no treatments available and the only licensed vaccine shows limited efficacy and is able to enhance the disease in some cases....
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963661/ https://www.ncbi.nlm.nih.gov/pubmed/31816907 http://dx.doi.org/10.3390/vaccines7040203 |
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author | Blight, Joshua Alves, Eduardo Reyes-Sandoval, Arturo |
author_facet | Blight, Joshua Alves, Eduardo Reyes-Sandoval, Arturo |
author_sort | Blight, Joshua |
collection | PubMed |
description | Over three billion are at risk of dengue infection with more than 100 million a year presenting with symptoms that can lead to deadly haemorrhagic disease. There are however no treatments available and the only licensed vaccine shows limited efficacy and is able to enhance the disease in some cases. These failures have mainly been due to the complex pathology and lack of understanding of the correlates of protection for dengue virus (DENV) infection. With increasing data suggesting both a protective and detrimental effect for antibodies and CD8 T-cells whilst having complex environmental dynamics. This review discusses the roles of genomic and immunological aspects of DENV infection, providing both a historical interpretation and fresh discussion on how this information can be used for the next generation of dengue interventions. |
format | Online Article Text |
id | pubmed-6963661 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69636612020-01-27 Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention Blight, Joshua Alves, Eduardo Reyes-Sandoval, Arturo Vaccines (Basel) Review Over three billion are at risk of dengue infection with more than 100 million a year presenting with symptoms that can lead to deadly haemorrhagic disease. There are however no treatments available and the only licensed vaccine shows limited efficacy and is able to enhance the disease in some cases. These failures have mainly been due to the complex pathology and lack of understanding of the correlates of protection for dengue virus (DENV) infection. With increasing data suggesting both a protective and detrimental effect for antibodies and CD8 T-cells whilst having complex environmental dynamics. This review discusses the roles of genomic and immunological aspects of DENV infection, providing both a historical interpretation and fresh discussion on how this information can be used for the next generation of dengue interventions. MDPI 2019-12-03 /pmc/articles/PMC6963661/ /pubmed/31816907 http://dx.doi.org/10.3390/vaccines7040203 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Blight, Joshua Alves, Eduardo Reyes-Sandoval, Arturo Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention |
title | Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention |
title_full | Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention |
title_fullStr | Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention |
title_full_unstemmed | Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention |
title_short | Considering Genomic and Immunological Correlates of Protection for a Dengue Intervention |
title_sort | considering genomic and immunological correlates of protection for a dengue intervention |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963661/ https://www.ncbi.nlm.nih.gov/pubmed/31816907 http://dx.doi.org/10.3390/vaccines7040203 |
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