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Vaccine Vectors Harnessing the Power of Cytomegaloviruses

Cytomegalovirus (CMV) species have been gaining attention as experimental vaccine vectors inducing cellular immune responses of unparalleled strength and protection. This review outline the strengths and the restrictions of CMV-based vectors, in light of the known aspects of CMV infection, pathogeni...

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Autores principales: Ynga-Durand, Mario Alberto, Dekhtiarenko, Iryna, Cicin-Sain, Luka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963789/
https://www.ncbi.nlm.nih.gov/pubmed/31627457
http://dx.doi.org/10.3390/vaccines7040152
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author Ynga-Durand, Mario Alberto
Dekhtiarenko, Iryna
Cicin-Sain, Luka
author_facet Ynga-Durand, Mario Alberto
Dekhtiarenko, Iryna
Cicin-Sain, Luka
author_sort Ynga-Durand, Mario Alberto
collection PubMed
description Cytomegalovirus (CMV) species have been gaining attention as experimental vaccine vectors inducing cellular immune responses of unparalleled strength and protection. This review outline the strengths and the restrictions of CMV-based vectors, in light of the known aspects of CMV infection, pathogenicity and immunity. We discuss aspects to be considered when optimizing CMV based vaccines, including the innate immune response, the adaptive humoral immunity and the T-cell responses. We also discuss the antigenic epitopes presented by unconventional major histocompatibility complex (MHC) molecules in some CMV delivery systems and considerations about routes for delivery for the induction of systemic or mucosal immune responses. With the first clinical trials initiating, CMV-based vaccine vectors are entering a mature phase of development. This impetus needs to be maintained by scientific advances that feed the progress of this technological platform.
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spelling pubmed-69637892020-01-27 Vaccine Vectors Harnessing the Power of Cytomegaloviruses Ynga-Durand, Mario Alberto Dekhtiarenko, Iryna Cicin-Sain, Luka Vaccines (Basel) Review Cytomegalovirus (CMV) species have been gaining attention as experimental vaccine vectors inducing cellular immune responses of unparalleled strength and protection. This review outline the strengths and the restrictions of CMV-based vectors, in light of the known aspects of CMV infection, pathogenicity and immunity. We discuss aspects to be considered when optimizing CMV based vaccines, including the innate immune response, the adaptive humoral immunity and the T-cell responses. We also discuss the antigenic epitopes presented by unconventional major histocompatibility complex (MHC) molecules in some CMV delivery systems and considerations about routes for delivery for the induction of systemic or mucosal immune responses. With the first clinical trials initiating, CMV-based vaccine vectors are entering a mature phase of development. This impetus needs to be maintained by scientific advances that feed the progress of this technological platform. MDPI 2019-10-17 /pmc/articles/PMC6963789/ /pubmed/31627457 http://dx.doi.org/10.3390/vaccines7040152 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ynga-Durand, Mario Alberto
Dekhtiarenko, Iryna
Cicin-Sain, Luka
Vaccine Vectors Harnessing the Power of Cytomegaloviruses
title Vaccine Vectors Harnessing the Power of Cytomegaloviruses
title_full Vaccine Vectors Harnessing the Power of Cytomegaloviruses
title_fullStr Vaccine Vectors Harnessing the Power of Cytomegaloviruses
title_full_unstemmed Vaccine Vectors Harnessing the Power of Cytomegaloviruses
title_short Vaccine Vectors Harnessing the Power of Cytomegaloviruses
title_sort vaccine vectors harnessing the power of cytomegaloviruses
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963789/
https://www.ncbi.nlm.nih.gov/pubmed/31627457
http://dx.doi.org/10.3390/vaccines7040152
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