A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations

The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a v...

Descripción completa

Detalles Bibliográficos
Autores principales: Lima-Barbero, José Francisco, Contreras, Marinela, Mateos-Hernández, Lourdes, Mata-Lorenzo, Francisco Manuel, Triguero-Ocaña, Roxana, Sparagano, Olivier, Finn, Robert D., Strube, Christina, Price, Daniel R.G., Nunn, Francesca, Bartley, Kathryn, Höfle, Ursula, Boadella, Mariana, Nisbet, Alasdair J., de la Fuente, José, Villar, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963798/
https://www.ncbi.nlm.nih.gov/pubmed/31756972
http://dx.doi.org/10.3390/vaccines7040190
Descripción
Sumario:The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control.

Ejemplares similares