A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations

The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a v...

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Autores principales: Lima-Barbero, José Francisco, Contreras, Marinela, Mateos-Hernández, Lourdes, Mata-Lorenzo, Francisco Manuel, Triguero-Ocaña, Roxana, Sparagano, Olivier, Finn, Robert D., Strube, Christina, Price, Daniel R.G., Nunn, Francesca, Bartley, Kathryn, Höfle, Ursula, Boadella, Mariana, Nisbet, Alasdair J., de la Fuente, José, Villar, Margarita
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963798/
https://www.ncbi.nlm.nih.gov/pubmed/31756972
http://dx.doi.org/10.3390/vaccines7040190
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author Lima-Barbero, José Francisco
Contreras, Marinela
Mateos-Hernández, Lourdes
Mata-Lorenzo, Francisco Manuel
Triguero-Ocaña, Roxana
Sparagano, Olivier
Finn, Robert D.
Strube, Christina
Price, Daniel R.G.
Nunn, Francesca
Bartley, Kathryn
Höfle, Ursula
Boadella, Mariana
Nisbet, Alasdair J.
de la Fuente, José
Villar, Margarita
author_facet Lima-Barbero, José Francisco
Contreras, Marinela
Mateos-Hernández, Lourdes
Mata-Lorenzo, Francisco Manuel
Triguero-Ocaña, Roxana
Sparagano, Olivier
Finn, Robert D.
Strube, Christina
Price, Daniel R.G.
Nunn, Francesca
Bartley, Kathryn
Höfle, Ursula
Boadella, Mariana
Nisbet, Alasdair J.
de la Fuente, José
Villar, Margarita
author_sort Lima-Barbero, José Francisco
collection PubMed
description The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control.
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spelling pubmed-69637982020-01-27 A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations Lima-Barbero, José Francisco Contreras, Marinela Mateos-Hernández, Lourdes Mata-Lorenzo, Francisco Manuel Triguero-Ocaña, Roxana Sparagano, Olivier Finn, Robert D. Strube, Christina Price, Daniel R.G. Nunn, Francesca Bartley, Kathryn Höfle, Ursula Boadella, Mariana Nisbet, Alasdair J. de la Fuente, José Villar, Margarita Vaccines (Basel) Article The poultry red mite (PRM), Dermanyssus gallinae, is a hematophagous ectoparasite considered as the major pest in the egg-laying industry. Its pesticide-based control is only partially successful and requires the development of new control interventions such as vaccines. In this study, we follow a vaccinology approach to identify PRM candidate protective antigens. Based on proteomic data from fed and unfed nymph and adult mites, we selected a novel PRM protein, calumenin (Deg-CALU), which is tested as a vaccine candidate on an on-hen trial. Rhipicephalus microplus Subolesin (Rhm-SUB) was chosen as a positive control. Deg-CALU and Rhm-SUB reduced the mite oviposition by 35 and 44%, respectively. These results support Deg-CALU and Rhm-SUB as candidate protective antigens for the PRM control. MDPI 2019-11-20 /pmc/articles/PMC6963798/ /pubmed/31756972 http://dx.doi.org/10.3390/vaccines7040190 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lima-Barbero, José Francisco
Contreras, Marinela
Mateos-Hernández, Lourdes
Mata-Lorenzo, Francisco Manuel
Triguero-Ocaña, Roxana
Sparagano, Olivier
Finn, Robert D.
Strube, Christina
Price, Daniel R.G.
Nunn, Francesca
Bartley, Kathryn
Höfle, Ursula
Boadella, Mariana
Nisbet, Alasdair J.
de la Fuente, José
Villar, Margarita
A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations
title A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations
title_full A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations
title_fullStr A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations
title_full_unstemmed A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations
title_short A Vaccinology Approach to the Identification and Characterization of Dermanyssus gallinae Candidate Protective Antigens for the Control of Poultry Red Mite Infestations
title_sort vaccinology approach to the identification and characterization of dermanyssus gallinae candidate protective antigens for the control of poultry red mite infestations
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963798/
https://www.ncbi.nlm.nih.gov/pubmed/31756972
http://dx.doi.org/10.3390/vaccines7040190
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