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Functional Cognitive Disorder: Diagnostic Challenges and Future Directions

Functional cognitive disorder describes patients with persistent, troublesome subjective cognitive complaints that are inconsistent with a recognized disease process, and where significant discrepancies are found between subjective and objectively observed cognitive functioning. The etiology is hete...

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Detalles Bibliográficos
Autores principales: Pennington, Catherine, Ball, Harriet, Swirski, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963804/
https://www.ncbi.nlm.nih.gov/pubmed/31569352
http://dx.doi.org/10.3390/diagnostics9040131
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author Pennington, Catherine
Ball, Harriet
Swirski, Marta
author_facet Pennington, Catherine
Ball, Harriet
Swirski, Marta
author_sort Pennington, Catherine
collection PubMed
description Functional cognitive disorder describes patients with persistent, troublesome subjective cognitive complaints that are inconsistent with a recognized disease process, and where significant discrepancies are found between subjective and objectively observed cognitive functioning. The etiology is heterogeneous and potentially related to underlying psychological factors. Making a diagnosis of functional cognitive disorder can be challenging and there is the potential for misdiagnosis of early-stage neurodegeneration. We compared neuropsychological findings in three groups: functional cognitive disorder (FCD), mild cognitive impairment (MCI), and healthy controls. Participants were recruited from the ReMemBr Group Clinic, North Bristol NHS Trust, and via Join Dementia Research. Both the FCD and MCI groups showed elevated prospective and retrospective memory symptom scores. Performance on the Montreal cognitive assessment was equivalent in the FCD and MCI groups, both being impaired compared with the controls. The FCD group was younger than those with MCI. We discuss challenges and controversies in the diagnosis of functional cognitive disorder, alongside illustrative cases and proposals for areas of research priority.
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spelling pubmed-69638042020-01-27 Functional Cognitive Disorder: Diagnostic Challenges and Future Directions Pennington, Catherine Ball, Harriet Swirski, Marta Diagnostics (Basel) Article Functional cognitive disorder describes patients with persistent, troublesome subjective cognitive complaints that are inconsistent with a recognized disease process, and where significant discrepancies are found between subjective and objectively observed cognitive functioning. The etiology is heterogeneous and potentially related to underlying psychological factors. Making a diagnosis of functional cognitive disorder can be challenging and there is the potential for misdiagnosis of early-stage neurodegeneration. We compared neuropsychological findings in three groups: functional cognitive disorder (FCD), mild cognitive impairment (MCI), and healthy controls. Participants were recruited from the ReMemBr Group Clinic, North Bristol NHS Trust, and via Join Dementia Research. Both the FCD and MCI groups showed elevated prospective and retrospective memory symptom scores. Performance on the Montreal cognitive assessment was equivalent in the FCD and MCI groups, both being impaired compared with the controls. The FCD group was younger than those with MCI. We discuss challenges and controversies in the diagnosis of functional cognitive disorder, alongside illustrative cases and proposals for areas of research priority. MDPI 2019-09-28 /pmc/articles/PMC6963804/ /pubmed/31569352 http://dx.doi.org/10.3390/diagnostics9040131 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pennington, Catherine
Ball, Harriet
Swirski, Marta
Functional Cognitive Disorder: Diagnostic Challenges and Future Directions
title Functional Cognitive Disorder: Diagnostic Challenges and Future Directions
title_full Functional Cognitive Disorder: Diagnostic Challenges and Future Directions
title_fullStr Functional Cognitive Disorder: Diagnostic Challenges and Future Directions
title_full_unstemmed Functional Cognitive Disorder: Diagnostic Challenges and Future Directions
title_short Functional Cognitive Disorder: Diagnostic Challenges and Future Directions
title_sort functional cognitive disorder: diagnostic challenges and future directions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963804/
https://www.ncbi.nlm.nih.gov/pubmed/31569352
http://dx.doi.org/10.3390/diagnostics9040131
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