13-(2-Methylbenzyl) Berberine Is a More Potent Inhibitor of MexXY-Dependent Aminoglycoside Resistance than Berberine

We previously showed that berberine attenuates MexXY efflux-dependent aminoglycoside resistance in Pseudomonas aeruginosa. Here, we aimed to synthesize berberine derivatives with higher MexXY inhibitory activities. We synthesized 11 berberine derivatives, of which 13-(2-methylbenzyl) berberine (13-o...

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Detalles Bibliográficos
Autores principales: Kotani, Kenta, Matsumura, Mio, Morita, Yuji, Tomida, Junko, Kutsuna, Ryo, Nishino, Kunihiko, Yasuike, Shuji, Kawamura, Yoshiaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6963850/
https://www.ncbi.nlm.nih.gov/pubmed/31698691
http://dx.doi.org/10.3390/antibiotics8040212

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