p66ShcA functions as a contextual promoter of breast cancer metastasis

BACKGROUND: The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli, p66ShcA becomes phosphorylated on serine 36, which allows it to translocate from the cytoplasm to the mitochondria where it stimulate...

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Detalles Bibliográficos
Autores principales: Lewis, Kyle, Kiepas, Alex, Hudson, Jesse, Senecal, Julien, Ha, Jacqueline R., Voorand, Elena, Annis, Matthew G., Sabourin, Valerie, Ahn, Ryuhjin, La Selva, Rachel, Tabariès, Sébastien, Hsu, Brian E., Siegel, Matthew J., Dankner, Matthew, Canedo, Eduardo Cepeda, Lajoie, Mathieu, Watson, Ian R., Brown, Claire M., Siegel, Peter M., Ursini-Siegel, Josie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964019/
https://www.ncbi.nlm.nih.gov/pubmed/31941526
http://dx.doi.org/10.1186/s13058-020-1245-6

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