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Lymphedema in three previously Wuchereria bancrofti-endemic health districts in Mali after cessation of mass drug administration

BACKGROUND: Lymphedema is a public health problem in countries with lymphatic filariasis (LF) including Mali. We studied the epidemiology and clinical presentation of lymphedema in three previously LF-endemic health districts of Mali after at least five consecutive rounds of mass drug administration...

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Autores principales: Dolo, Housseini, Coulibaly, Yaya Ibrahim, Konipo, Fatoumata Nene, Coulibaly, Siaka Yamoussa, Doumbia, Salif Seriba, Sangare, Moussa Brema, Soumaoro, Lamine, Coulibaly, Michel Emmanuel, Diallo, Abdallah Amadou, Diarra, Yaye, Sangare, Modibo, Doumbia, Seydou, Colebunders, Robert, Nutman, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964034/
https://www.ncbi.nlm.nih.gov/pubmed/31941448
http://dx.doi.org/10.1186/s12879-020-4777-6
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author Dolo, Housseini
Coulibaly, Yaya Ibrahim
Konipo, Fatoumata Nene
Coulibaly, Siaka Yamoussa
Doumbia, Salif Seriba
Sangare, Moussa Brema
Soumaoro, Lamine
Coulibaly, Michel Emmanuel
Diallo, Abdallah Amadou
Diarra, Yaye
Sangare, Modibo
Doumbia, Seydou
Colebunders, Robert
Nutman, Thomas B.
author_facet Dolo, Housseini
Coulibaly, Yaya Ibrahim
Konipo, Fatoumata Nene
Coulibaly, Siaka Yamoussa
Doumbia, Salif Seriba
Sangare, Moussa Brema
Soumaoro, Lamine
Coulibaly, Michel Emmanuel
Diallo, Abdallah Amadou
Diarra, Yaye
Sangare, Modibo
Doumbia, Seydou
Colebunders, Robert
Nutman, Thomas B.
author_sort Dolo, Housseini
collection PubMed
description BACKGROUND: Lymphedema is a public health problem in countries with lymphatic filariasis (LF) including Mali. We studied the epidemiology and clinical presentation of lymphedema in three previously LF-endemic health districts of Mali after at least five consecutive rounds of mass drug administration (MDA) with albendazole and ivermectin. METHODS: From 2016 to 2018, we used passive and active case finding methods to identify lymphedema cases in three health districts with high pre-MDA LF prevalence: Kolondieba (66%), Bougouni (44%) and Kolokani (34%). RESULTS: Three hundred and thirty nine cases of lymphedema were identified, 235 (69.32%) through active case finding. Their median age was 56 years (range 2–90) and 286 (84.36%) were women. Lymphedema was reported in 226 (78.5%) people aged 41 years and older compared to 73 (21.5%) people below the age of 41 years (Chi(2) = 17.28, df = 5, p = 0.004). One hundred and seventy five cases of lymphedema were found in Kolondieba (66 per 100,000 people), 116 in Bougouni (19 per 100,000) and 48 in Kolokani (16 per 100,000). Stage III lymphedema was observed in 131 (38.64%), stage II in 108 (31.86%), stage IV in 46 (13.57%), stage I in 23 (6.78%), stage V in 21 (6.19%) and stage VI in ten (2.95%). In the three study districts, lymphedema affected the legs in 281 (82.89%), the arms in 42 (12.39%) and both in 16 (4.72%) (Chi2 = 13.63, p = 0.008). CONCLUSION: Health districts in Mali with the highest pre-MDA LF prevalences had the highest prevalence of lymphedema. Efforts to actively identify lymphedema cases should be scaled up in previous LF-endemic areas, and should be supplemented by a morbidity management and disability prevention plan at the peripheral health system level.
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spelling pubmed-69640342020-01-22 Lymphedema in three previously Wuchereria bancrofti-endemic health districts in Mali after cessation of mass drug administration Dolo, Housseini Coulibaly, Yaya Ibrahim Konipo, Fatoumata Nene Coulibaly, Siaka Yamoussa Doumbia, Salif Seriba Sangare, Moussa Brema Soumaoro, Lamine Coulibaly, Michel Emmanuel Diallo, Abdallah Amadou Diarra, Yaye Sangare, Modibo Doumbia, Seydou Colebunders, Robert Nutman, Thomas B. BMC Infect Dis Research Article BACKGROUND: Lymphedema is a public health problem in countries with lymphatic filariasis (LF) including Mali. We studied the epidemiology and clinical presentation of lymphedema in three previously LF-endemic health districts of Mali after at least five consecutive rounds of mass drug administration (MDA) with albendazole and ivermectin. METHODS: From 2016 to 2018, we used passive and active case finding methods to identify lymphedema cases in three health districts with high pre-MDA LF prevalence: Kolondieba (66%), Bougouni (44%) and Kolokani (34%). RESULTS: Three hundred and thirty nine cases of lymphedema were identified, 235 (69.32%) through active case finding. Their median age was 56 years (range 2–90) and 286 (84.36%) were women. Lymphedema was reported in 226 (78.5%) people aged 41 years and older compared to 73 (21.5%) people below the age of 41 years (Chi(2) = 17.28, df = 5, p = 0.004). One hundred and seventy five cases of lymphedema were found in Kolondieba (66 per 100,000 people), 116 in Bougouni (19 per 100,000) and 48 in Kolokani (16 per 100,000). Stage III lymphedema was observed in 131 (38.64%), stage II in 108 (31.86%), stage IV in 46 (13.57%), stage I in 23 (6.78%), stage V in 21 (6.19%) and stage VI in ten (2.95%). In the three study districts, lymphedema affected the legs in 281 (82.89%), the arms in 42 (12.39%) and both in 16 (4.72%) (Chi2 = 13.63, p = 0.008). CONCLUSION: Health districts in Mali with the highest pre-MDA LF prevalences had the highest prevalence of lymphedema. Efforts to actively identify lymphedema cases should be scaled up in previous LF-endemic areas, and should be supplemented by a morbidity management and disability prevention plan at the peripheral health system level. BioMed Central 2020-01-15 /pmc/articles/PMC6964034/ /pubmed/31941448 http://dx.doi.org/10.1186/s12879-020-4777-6 Text en © The Author(s). 2020 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Dolo, Housseini
Coulibaly, Yaya Ibrahim
Konipo, Fatoumata Nene
Coulibaly, Siaka Yamoussa
Doumbia, Salif Seriba
Sangare, Moussa Brema
Soumaoro, Lamine
Coulibaly, Michel Emmanuel
Diallo, Abdallah Amadou
Diarra, Yaye
Sangare, Modibo
Doumbia, Seydou
Colebunders, Robert
Nutman, Thomas B.
Lymphedema in three previously Wuchereria bancrofti-endemic health districts in Mali after cessation of mass drug administration
title Lymphedema in three previously Wuchereria bancrofti-endemic health districts in Mali after cessation of mass drug administration
title_full Lymphedema in three previously Wuchereria bancrofti-endemic health districts in Mali after cessation of mass drug administration
title_fullStr Lymphedema in three previously Wuchereria bancrofti-endemic health districts in Mali after cessation of mass drug administration
title_full_unstemmed Lymphedema in three previously Wuchereria bancrofti-endemic health districts in Mali after cessation of mass drug administration
title_short Lymphedema in three previously Wuchereria bancrofti-endemic health districts in Mali after cessation of mass drug administration
title_sort lymphedema in three previously wuchereria bancrofti-endemic health districts in mali after cessation of mass drug administration
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964034/
https://www.ncbi.nlm.nih.gov/pubmed/31941448
http://dx.doi.org/10.1186/s12879-020-4777-6
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