The Pan‐Cancer Landscape of Coamplification of the Tyrosine Kinases KIT, KDR, and PDGFRA

PURPOSE: Amplifications of receptor tyrosine kinases (RTKS) are therapeutic targets in multiple tumor types (e.g. HER2 in breast cancer), and amplification of the chromosome 4 segment harboring the three RTKs KIT, PDGFRA, and KDR (4q12amp) may be similarly targetable. The presence of 4q12amp has bee...

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Detalles Bibliográficos
Autores principales: Disel, Umut, Madison, Russell, Abhishek, Kumar, Chung, Jon H., Trabucco, Sally E., Matos, Asli O., Frampton, Garrett M., Albacker, Lee A., Reddy, Venkataprasanth, Karadurmus, Nuri, Benson, Adam, Webster, Jennifer, Paydas, Semra, Cabanillas, Ruben, Nangia, Chaitali, Ozturk, M.A., Millis, Sherri Z., Pal, Sumanta K., Wilky, Breelyn, Sokol, Ethan S., Gay, Laurie M., Soman, Salil, Ganesan, Shridar, Janeway, Katherine, Stephens, Phil J., Zhu, Viola W., Ou, Sai‐Hong Ignatius, Lovly, Christine M., Gounder, Mrinal, Schrock, Alexa B., Ross, Jeffrey S., Miller, Vincent A., Klempner, Samuel J., Ali, Siraj M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2019
Materias:
Cancer Diagnostics and Molecular Pathology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964135/
https://www.ncbi.nlm.nih.gov/pubmed/31604903
http://dx.doi.org/10.1634/theoncologist.2018-0528

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