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Phase Ib Study of Combination Therapy with MEK Inhibitor Binimetinib and Phosphatidylinositol 3‐Kinase Inhibitor Buparlisib in Patients with Advanced Solid Tumors with RAS/RAF Alterations

BACKGROUND: This multicenter, open‐label, phase Ib study investigated the safety and efficacy of binimetinib (MEK inhibitor) in combination with buparlisib (phosphatidylinositol 3‐kinase [PI3K] inhibitor) in patients with advanced solid tumors with RAS/RAF alterations. MATERIALS AND METHODS: Eighty‐...

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Detalles Bibliográficos
Autores principales:	Bardia, Aditya, Gounder, Mrinal, Rodon, Jordi, Janku, Filip, Lolkema, Martijn P., Stephenson, Joe J., Bedard, Philippe L., Schuler, Martin, Sessa, Cristiana, LoRusso, Patricia, Thomas, Michael, Maacke, Heiko, Evans, Helen, Sun, Yongjian, Tan, Daniel S.W.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley & Sons, Inc. 2019
Materias:	New Drug Development and Clinical Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964137/ https://www.ncbi.nlm.nih.gov/pubmed/31395751 http://dx.doi.org/10.1634/theoncologist.2019-0297

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