A Conserved Noncoding Locus Regulates Random Monoallelic Xist Expression across a Topological Boundary

cis-Regulatory communication is crucial in mammalian development and is thought to be restricted by the spatial partitioning of the genome in topologically associating domains (TADs). Here, we discovered that the Xist locus is regulated by sequences in the neighboring TAD. In particular, the promote...

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Detalles Bibliográficos
Autores principales: Galupa, Rafael, Nora, Elphège Pierre, Worsley-Hunt, Rebecca, Picard, Christel, Gard, Chris, van Bemmel, Joke Gerarda, Servant, Nicolas, Zhan, Yinxiu, El Marjou, Fatima, Johanneau, Colin, Diabangouaya, Patricia, Le Saux, Agnès, Lameiras, Sonia, Pipoli da Fonseca, Juliana, Loos, Friedemann, Gribnau, Joost, Baulande, Sylvain, Ohler, Uwe, Giorgetti, Luca, Heard, Edith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964159/
https://www.ncbi.nlm.nih.gov/pubmed/31759823
http://dx.doi.org/10.1016/j.molcel.2019.10.030

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