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Synthesis and Evaluation of Artemisinin-Based Hybrid and Dimer Derivatives as Antimelanoma Agents
[Image: see text] A library of hybrid and dimer compounds based on the natural scaffold of artemisinin was synthesized. These derivatives were obtained by coupling of artemisinin derivatives, artesunate, and dihydroartemisinin with a panel of phytochemical compounds. The novel artemisinin-based hybr...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical
Society
2019
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964273/ https://www.ncbi.nlm.nih.gov/pubmed/31956771 http://dx.doi.org/10.1021/acsomega.9b02600 |
| _version_ | 1783488454400671744 |
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| author | Botta, Lorenzo Filippi, Silvia Bizzarri, Bruno M. Zippilli, Claudio Meschini, Roberta Pogni, Rebecca Baratto, Maria Camilla Villanova, Luciano Saladino, Raffaele |
| author_facet | Botta, Lorenzo Filippi, Silvia Bizzarri, Bruno M. Zippilli, Claudio Meschini, Roberta Pogni, Rebecca Baratto, Maria Camilla Villanova, Luciano Saladino, Raffaele |
| author_sort | Botta, Lorenzo |
| collection | PubMed |
| description | [Image: see text] A library of hybrid and dimer compounds based on the natural scaffold of artemisinin was synthesized. These derivatives were obtained by coupling of artemisinin derivatives, artesunate, and dihydroartemisinin with a panel of phytochemical compounds. The novel artemisinin-based hybrids and dimers were evaluated for their anticancer activity on a cervical cancer cell line (HeLa) and on three complementary metastatic melanoma cancer cell lines (SK-MEL3, SK-MEL24, and RPMI-7951). Two hybrid compounds obtained by coupling of artesunate with eugenol and tyrosol, and one of the dimer compounds containing curcumin, emerged as the most active and cancer-selective derivatives. |
| format | Online Article Text |
| id | pubmed-6964273 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2019 |
| publisher | American Chemical
Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-69642732020-01-17 Synthesis and Evaluation of Artemisinin-Based Hybrid and Dimer Derivatives as Antimelanoma Agents Botta, Lorenzo Filippi, Silvia Bizzarri, Bruno M. Zippilli, Claudio Meschini, Roberta Pogni, Rebecca Baratto, Maria Camilla Villanova, Luciano Saladino, Raffaele ACS Omega [Image: see text] A library of hybrid and dimer compounds based on the natural scaffold of artemisinin was synthesized. These derivatives were obtained by coupling of artemisinin derivatives, artesunate, and dihydroartemisinin with a panel of phytochemical compounds. The novel artemisinin-based hybrids and dimers were evaluated for their anticancer activity on a cervical cancer cell line (HeLa) and on three complementary metastatic melanoma cancer cell lines (SK-MEL3, SK-MEL24, and RPMI-7951). Two hybrid compounds obtained by coupling of artesunate with eugenol and tyrosol, and one of the dimer compounds containing curcumin, emerged as the most active and cancer-selective derivatives. American Chemical Society 2019-12-27 /pmc/articles/PMC6964273/ /pubmed/31956771 http://dx.doi.org/10.1021/acsomega.9b02600 Text en Copyright © 2019 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes. |
| spellingShingle | Botta, Lorenzo Filippi, Silvia Bizzarri, Bruno M. Zippilli, Claudio Meschini, Roberta Pogni, Rebecca Baratto, Maria Camilla Villanova, Luciano Saladino, Raffaele Synthesis and Evaluation of Artemisinin-Based Hybrid and Dimer Derivatives as Antimelanoma Agents |
| title | Synthesis and Evaluation
of Artemisinin-Based Hybrid
and Dimer Derivatives as Antimelanoma Agents |
| title_full | Synthesis and Evaluation
of Artemisinin-Based Hybrid
and Dimer Derivatives as Antimelanoma Agents |
| title_fullStr | Synthesis and Evaluation
of Artemisinin-Based Hybrid
and Dimer Derivatives as Antimelanoma Agents |
| title_full_unstemmed | Synthesis and Evaluation
of Artemisinin-Based Hybrid
and Dimer Derivatives as Antimelanoma Agents |
| title_short | Synthesis and Evaluation
of Artemisinin-Based Hybrid
and Dimer Derivatives as Antimelanoma Agents |
| title_sort | synthesis and evaluation
of artemisinin-based hybrid
and dimer derivatives as antimelanoma agents |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964273/ https://www.ncbi.nlm.nih.gov/pubmed/31956771 http://dx.doi.org/10.1021/acsomega.9b02600 |
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