Methoxymethyl Threofuranosyl Thymidine (4′-MOM-TNA-T) at the T7 Position of the Thrombin-Binding Aptamer Boosts Anticoagulation Activity, Thermal Stability, and Nuclease Resistance

[Image: see text] The synthesis of 4′-methoxymethyl threofuranosyl (4′-MOM-TNA) thymidine and derived oligomers of the G-rich thrombin-binding aptameric (TBA) sequence is reported. The G-quadruplex stability, anticoagulation activity, and the enzymatic stability of these oligomers bearing the 2′-3′-...

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Autores principales: Varada, Manojkumar, Aher, Manisha, Erande, Namrata, Kumar, Vaijayanti A., Fernandes, Moneesha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964305/
https://www.ncbi.nlm.nih.gov/pubmed/31956796
http://dx.doi.org/10.1021/acsomega.9b03042

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