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Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers

Aim: Magnetic resonance imaging (MRI) is increasingly being used to evaluate brown adipose tissue (BAT) function. Reports on the extent and direction of cold-induced changes in MRI fat fraction and estimated BAT volume vary between studies. Here, we aimed to explore the effect of different fat fract...

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Autores principales: Abreu-Vieira, Gustavo, Sardjoe Mishre, Aashley S. D., Burakiewicz, Jedrzej, Janssen, Laura G. M., Nahon, Kimberly J., van der Eijk, Jari A., Riem, Titia T., Boon, Mariëtte R., Dzyubachyk, Oleh, Webb, Andrew G., Rensen, Patrick C. N., Kan, Hermien E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964318/
https://www.ncbi.nlm.nih.gov/pubmed/31998233
http://dx.doi.org/10.3389/fendo.2019.00898
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author Abreu-Vieira, Gustavo
Sardjoe Mishre, Aashley S. D.
Burakiewicz, Jedrzej
Janssen, Laura G. M.
Nahon, Kimberly J.
van der Eijk, Jari A.
Riem, Titia T.
Boon, Mariëtte R.
Dzyubachyk, Oleh
Webb, Andrew G.
Rensen, Patrick C. N.
Kan, Hermien E.
author_facet Abreu-Vieira, Gustavo
Sardjoe Mishre, Aashley S. D.
Burakiewicz, Jedrzej
Janssen, Laura G. M.
Nahon, Kimberly J.
van der Eijk, Jari A.
Riem, Titia T.
Boon, Mariëtte R.
Dzyubachyk, Oleh
Webb, Andrew G.
Rensen, Patrick C. N.
Kan, Hermien E.
author_sort Abreu-Vieira, Gustavo
collection PubMed
description Aim: Magnetic resonance imaging (MRI) is increasingly being used to evaluate brown adipose tissue (BAT) function. Reports on the extent and direction of cold-induced changes in MRI fat fraction and estimated BAT volume vary between studies. Here, we aimed to explore the effect of different fat fraction threshold ranges on outcomes measured by MRI. Moreover, we aimed to investigate the effect of cold exposure on estimated BAT mass and energy content. Methods: The effects of cold exposure at different fat fraction thresholding levels were analyzed in the supraclavicular adipose depot of nine adult males. MRI data were reconstructed, co-registered and analyzed in two ways. First, we analyzed cold-induced changes in fat fraction, T2* relaxation time, volume, mass, and energy of the entire supraclavicular adipose depot at different fat fraction threshold levels. As a control, we assessed fat fraction differences of deltoid subcutaneous adipose tissue (SAT). Second, a local analysis was performed to study changes in fat fraction and T2* on a voxel-level. Thermoneutral and post-cooling data were compared using paired-sample t-tests (p < 0.05). Results: Global analysis unveiled that the largest cold-induced change in fat fraction occurred within a thermoneutral fat fraction range of 30–100% (−3.5 ± 1.9%), without changing the estimated BAT volume. However, the largest cold-induced changes in estimated BAT volume were observed when applying a thermoneutral fat fraction range of 70–100% (−3.8 ± 2.6%). No changes were observed for the deltoid SAT fat fractions. Tissue energy content was reduced from 126 ± 33 to 121 ± 30 kcal, when using a 30–100% fat fraction range, and also depended on different fat fraction thresholds. Voxel-wise analysis showed that while cold exposure changed the fat fraction across nearly all thermoneutral fat fractions, decreases were most pronounced at high thermoneutral fat fractions. Conclusion: Cold-induced changes in fat fraction occurred over the entire range of thermoneutral fat fractions, and were especially found in lipid-rich regions of the supraclavicular adipose depot. Due to the variability in response between lipid-rich and lipid-poor regions, care should be taken when applying fat fraction thresholds for MRI BAT analysis.
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spelling pubmed-69643182020-01-29 Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers Abreu-Vieira, Gustavo Sardjoe Mishre, Aashley S. D. Burakiewicz, Jedrzej Janssen, Laura G. M. Nahon, Kimberly J. van der Eijk, Jari A. Riem, Titia T. Boon, Mariëtte R. Dzyubachyk, Oleh Webb, Andrew G. Rensen, Patrick C. N. Kan, Hermien E. Front Endocrinol (Lausanne) Endocrinology Aim: Magnetic resonance imaging (MRI) is increasingly being used to evaluate brown adipose tissue (BAT) function. Reports on the extent and direction of cold-induced changes in MRI fat fraction and estimated BAT volume vary between studies. Here, we aimed to explore the effect of different fat fraction threshold ranges on outcomes measured by MRI. Moreover, we aimed to investigate the effect of cold exposure on estimated BAT mass and energy content. Methods: The effects of cold exposure at different fat fraction thresholding levels were analyzed in the supraclavicular adipose depot of nine adult males. MRI data were reconstructed, co-registered and analyzed in two ways. First, we analyzed cold-induced changes in fat fraction, T2* relaxation time, volume, mass, and energy of the entire supraclavicular adipose depot at different fat fraction threshold levels. As a control, we assessed fat fraction differences of deltoid subcutaneous adipose tissue (SAT). Second, a local analysis was performed to study changes in fat fraction and T2* on a voxel-level. Thermoneutral and post-cooling data were compared using paired-sample t-tests (p < 0.05). Results: Global analysis unveiled that the largest cold-induced change in fat fraction occurred within a thermoneutral fat fraction range of 30–100% (−3.5 ± 1.9%), without changing the estimated BAT volume. However, the largest cold-induced changes in estimated BAT volume were observed when applying a thermoneutral fat fraction range of 70–100% (−3.8 ± 2.6%). No changes were observed for the deltoid SAT fat fractions. Tissue energy content was reduced from 126 ± 33 to 121 ± 30 kcal, when using a 30–100% fat fraction range, and also depended on different fat fraction thresholds. Voxel-wise analysis showed that while cold exposure changed the fat fraction across nearly all thermoneutral fat fractions, decreases were most pronounced at high thermoneutral fat fractions. Conclusion: Cold-induced changes in fat fraction occurred over the entire range of thermoneutral fat fractions, and were especially found in lipid-rich regions of the supraclavicular adipose depot. Due to the variability in response between lipid-rich and lipid-poor regions, care should be taken when applying fat fraction thresholds for MRI BAT analysis. Frontiers Media S.A. 2020-01-09 /pmc/articles/PMC6964318/ /pubmed/31998233 http://dx.doi.org/10.3389/fendo.2019.00898 Text en Copyright © 2020 Abreu-Vieira, Sardjoe Mishre, Burakiewicz, Janssen, Nahon, van der Eijk, Riem, Boon, Dzyubachyk, Webb, Rensen and Kan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Abreu-Vieira, Gustavo
Sardjoe Mishre, Aashley S. D.
Burakiewicz, Jedrzej
Janssen, Laura G. M.
Nahon, Kimberly J.
van der Eijk, Jari A.
Riem, Titia T.
Boon, Mariëtte R.
Dzyubachyk, Oleh
Webb, Andrew G.
Rensen, Patrick C. N.
Kan, Hermien E.
Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers
title Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers
title_full Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers
title_fullStr Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers
title_full_unstemmed Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers
title_short Human Brown Adipose Tissue Estimated With Magnetic Resonance Imaging Undergoes Changes in Composition After Cold Exposure: An in vivo MRI Study in Healthy Volunteers
title_sort human brown adipose tissue estimated with magnetic resonance imaging undergoes changes in composition after cold exposure: an in vivo mri study in healthy volunteers
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964318/
https://www.ncbi.nlm.nih.gov/pubmed/31998233
http://dx.doi.org/10.3389/fendo.2019.00898
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