PDE6D Inhibitors with a New Design Principle Selectively Block K-Ras Activity

[Image: see text] The trafficking chaperone PDE6D (also referred to as PDEδ) has been nominated as a surrogate target for K-Ras4B (hereafter K-Ras). Arl2-assisted unloading of K-Ras from PDE6D in the perinuclear area is significant for correct K-Ras localization and therefore activity. However, the...

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Detalles Bibliográficos
Autores principales: Siddiqui, Farid A., Alam, Catharina, Rosenqvist, Petja, Ora, Mikko, Sabt, Ahmed, Manoharan, Ganesh babu, Bindu, Lakshman, Okutachi, Sunday, Catillon, Marie, Taylor, Troy, Abdelhafez, Omaima M., Lönnberg, Harri, Stephen, Andrew G., Papageorgiou, Anastassios C., Virta, Pasi, Abankwa, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2019
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964506/
https://www.ncbi.nlm.nih.gov/pubmed/31956834
http://dx.doi.org/10.1021/acsomega.9b03639

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