Functionalization of the imidazo[1,2-a]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted Mizoroki–Heck reaction

A series of new phosphonocarboxylates containing an imidazo[1,2-a]pyridine ring has been synthesized via the microwave-assisted Mizoroki–Heck reaction. The efficient modification of the imidazo[1,2-a]pyridine ring has been achieved as late-stage functionalization, enabling and accelerating the gener...

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Autores principales: Kusy, Damian, Wojciechowska, Agata, Małolepsza, Joanna, Błażewska, Katarzyna M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Beilstein-Institut 2020
Materias:
Full Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964661/
https://www.ncbi.nlm.nih.gov/pubmed/31976012
http://dx.doi.org/10.3762/bjoc.16.3
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author Kusy, Damian
Wojciechowska, Agata
Małolepsza, Joanna
Błażewska, Katarzyna M
author_facet Kusy, Damian
Wojciechowska, Agata
Małolepsza, Joanna
Błażewska, Katarzyna M
author_sort Kusy, Damian
collection PubMed
description A series of new phosphonocarboxylates containing an imidazo[1,2-a]pyridine ring has been synthesized via the microwave-assisted Mizoroki–Heck reaction. The efficient modification of the imidazo[1,2-a]pyridine ring has been achieved as late-stage functionalization, enabling and accelerating the generation of a library of compounds from a common precursor.
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spelling pubmed-69646612020-01-23 Functionalization of the imidazo[1,2-a]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted Mizoroki–Heck reaction Kusy, Damian Wojciechowska, Agata Małolepsza, Joanna Błażewska, Katarzyna M Beilstein J Org Chem Full Research Paper A series of new phosphonocarboxylates containing an imidazo[1,2-a]pyridine ring has been synthesized via the microwave-assisted Mizoroki–Heck reaction. The efficient modification of the imidazo[1,2-a]pyridine ring has been achieved as late-stage functionalization, enabling and accelerating the generation of a library of compounds from a common precursor. Beilstein-Institut 2020-01-03 /pmc/articles/PMC6964661/ /pubmed/31976012 http://dx.doi.org/10.3762/bjoc.16.3 Text en Copyright © 2020, Kusy et al. https://creativecommons.org/licenses/by/4.0https://www.beilstein-journals.org/bjoc/termsThis is an Open Access article under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0). Please note that the reuse, redistribution and reproduction in particular requires that the authors and source are credited. The license is subject to the Beilstein Journal of Organic Chemistry terms and conditions: (https://www.beilstein-journals.org/bjoc/terms)
spellingShingle Full Research Paper
Kusy, Damian
Wojciechowska, Agata
Małolepsza, Joanna
Błażewska, Katarzyna M
Functionalization of the imidazo[1,2-a]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted Mizoroki–Heck reaction
title Functionalization of the imidazo[1,2-a]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted Mizoroki–Heck reaction
title_full Functionalization of the imidazo[1,2-a]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted Mizoroki–Heck reaction
title_fullStr Functionalization of the imidazo[1,2-a]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted Mizoroki–Heck reaction
title_full_unstemmed Functionalization of the imidazo[1,2-a]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted Mizoroki–Heck reaction
title_short Functionalization of the imidazo[1,2-a]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted Mizoroki–Heck reaction
title_sort functionalization of the imidazo[1,2-a]pyridine ring in α-phosphonoacrylates and α-phosphonopropionates via microwave-assisted mizoroki–heck reaction
topic Full Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964661/
https://www.ncbi.nlm.nih.gov/pubmed/31976012
http://dx.doi.org/10.3762/bjoc.16.3
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