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Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer
BACKGROUND: L1 cell adhesion molecule (L1CAM) is highly expressed in malignant tumours and might play a pivotal role in tumour progression. METHODS: We analysed by immunohistochemistry L1CAM protein expression in formalin-fixed, paraffin-embedded specimens from 309 GC patients. We performed propensi...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964673/ https://www.ncbi.nlm.nih.gov/pubmed/31754264 http://dx.doi.org/10.1038/s41416-019-0646-8 |
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author | Ichikawa, Takashi Okugawa, Yoshinaga Toiyama, Yuji Tanaka, Koji Yin, Chengzeng Kitajima, Takahito Kondo, Satoru Shimura, Tadanobu Ohi, Masaki Araki, Toshimitsu Kusunoki, Masato |
author_facet | Ichikawa, Takashi Okugawa, Yoshinaga Toiyama, Yuji Tanaka, Koji Yin, Chengzeng Kitajima, Takahito Kondo, Satoru Shimura, Tadanobu Ohi, Masaki Araki, Toshimitsu Kusunoki, Masato |
author_sort | Ichikawa, Takashi |
collection | PubMed |
description | BACKGROUND: L1 cell adhesion molecule (L1CAM) is highly expressed in malignant tumours and might play a pivotal role in tumour progression. METHODS: We analysed by immunohistochemistry L1CAM protein expression in formalin-fixed, paraffin-embedded specimens from 309 GC patients. We performed propensity score matching (PSM) analysis to clarify the prognostic impact of L1CAM in GC patients. We evaluated L1CAM gene expression in fresh frozen specimens from another group of 131 GC patients to establish its clinical relevance. The effects of changes in L1CAM were investigated in vitro and in vivo. RESULTS: L1CAM was mainly expressed in tumour cells of GC tissues. Elevated L1CAM expression was an independent prognostic factor for overall and disease-free survival, and an independent risk factor for distant metastasis in GC patients. PSM analysis showed that high L1CAM expression was significantly associated with poor prognosis. L1CAM gene expression using fresh frozen specimens successfully validated all of these findings in an independent cohort. Inhibition of L1CAM suppressed cell proliferation, cycle progress, invasion, migration and anoikis resistance in GC cells. Furthermore, L1CAM inhibition suppressed the growth of peritoneal metastasis. CONCLUSION: L1CAM may serve as a feasible biomarker for identification of patients who have a high risk of recurrence of GC. |
format | Online Article Text |
id | pubmed-6964673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69646732020-11-22 Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer Ichikawa, Takashi Okugawa, Yoshinaga Toiyama, Yuji Tanaka, Koji Yin, Chengzeng Kitajima, Takahito Kondo, Satoru Shimura, Tadanobu Ohi, Masaki Araki, Toshimitsu Kusunoki, Masato Br J Cancer Article BACKGROUND: L1 cell adhesion molecule (L1CAM) is highly expressed in malignant tumours and might play a pivotal role in tumour progression. METHODS: We analysed by immunohistochemistry L1CAM protein expression in formalin-fixed, paraffin-embedded specimens from 309 GC patients. We performed propensity score matching (PSM) analysis to clarify the prognostic impact of L1CAM in GC patients. We evaluated L1CAM gene expression in fresh frozen specimens from another group of 131 GC patients to establish its clinical relevance. The effects of changes in L1CAM were investigated in vitro and in vivo. RESULTS: L1CAM was mainly expressed in tumour cells of GC tissues. Elevated L1CAM expression was an independent prognostic factor for overall and disease-free survival, and an independent risk factor for distant metastasis in GC patients. PSM analysis showed that high L1CAM expression was significantly associated with poor prognosis. L1CAM gene expression using fresh frozen specimens successfully validated all of these findings in an independent cohort. Inhibition of L1CAM suppressed cell proliferation, cycle progress, invasion, migration and anoikis resistance in GC cells. Furthermore, L1CAM inhibition suppressed the growth of peritoneal metastasis. CONCLUSION: L1CAM may serve as a feasible biomarker for identification of patients who have a high risk of recurrence of GC. Nature Publishing Group UK 2019-11-22 2019-12-10 /pmc/articles/PMC6964673/ /pubmed/31754264 http://dx.doi.org/10.1038/s41416-019-0646-8 Text en © The Author(s), under exclusive licence to Cancer Research UK 2019 https://creativecommons.org/licenses/by/4.0/Note: This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution 4.0 International (CC BY 4.0). |
spellingShingle | Article Ichikawa, Takashi Okugawa, Yoshinaga Toiyama, Yuji Tanaka, Koji Yin, Chengzeng Kitajima, Takahito Kondo, Satoru Shimura, Tadanobu Ohi, Masaki Araki, Toshimitsu Kusunoki, Masato Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer |
title | Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer |
title_full | Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer |
title_fullStr | Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer |
title_full_unstemmed | Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer |
title_short | Clinical significance and biological role of L1 cell adhesion molecule in gastric cancer |
title_sort | clinical significance and biological role of l1 cell adhesion molecule in gastric cancer |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964673/ https://www.ncbi.nlm.nih.gov/pubmed/31754264 http://dx.doi.org/10.1038/s41416-019-0646-8 |
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