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HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer

BACKGROUND: Tamoxifen resistance remains a significant clinical challenge for the therapy of ER-positive breast cancer. It has been reported that the upregulation of transcription factor SOX9 in ER(+) recurrent cancer is sufficient for tamoxifen resistance. However, the mechanisms underlying the reg...

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Detalles Bibliográficos
Autores principales:	Xue, Yue, Lian, Wenwen, Zhi, Jiaqi, Yang, Wenjuan, Li, Qianjin, Guo, Xingyi, Gao, Jiahao, Qu, Hao, Lin, Weiqiang, Li, Zhongqi, Lai, Lihua, Wang, Qingqing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964674/ https://www.ncbi.nlm.nih.gov/pubmed/31690832 http://dx.doi.org/10.1038/s41416-019-0625-0

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