Systematic chemical screening identifies disulfiram as a repurposed drug that enhances sensitivity to cisplatin in bladder cancer: a summary of preclinical studies

BACKGROUND: Since the standard gemcitabine and cisplatin (GC) chemotherapy for advanced bladder cancer yields limited therapeutic effect due to chemoresistance, it is a clinical challenge to enhance sensitivity to GC. METHODS: We performed high-throughput screening by using a library of known chemic...

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Detalles Bibliográficos
Autores principales: Kita, Yuki, Hamada, Akihiro, Saito, Ryoichi, Teramoto, Yuki, Tanaka, Ryusuke, Takano, Keishi, Nakayama, Kenji, Murakami, Kaoru, Matsumoto, Keiyu, Akamatsu, Shusuke, Yamasaki, Toshinari, Inoue, Takahiro, Tabata, Yasuhiko, Okuno, Yasushi, Ogawa, Osamu, Kobayashi, Takashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964684/
https://www.ncbi.nlm.nih.gov/pubmed/31673101
http://dx.doi.org/10.1038/s41416-019-0609-0

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