Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement

Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). Actin cytoskeleton rearrangement in podocyte induced by multiple pathogenic factors is believed to be the key process resulting in glomerular injury. Many studies have recentl...

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Autores principales: Wang, Qian, Tian, Xuefei, Wang, Yuyang, Wang, Yan, Li, Jialin, Zhao, Tingting, Li, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2020
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964719/
https://www.ncbi.nlm.nih.gov/pubmed/31998809
http://dx.doi.org/10.1155/2020/6897390
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author Wang, Qian
Tian, Xuefei
Wang, Yuyang
Wang, Yan
Li, Jialin
Zhao, Tingting
Li, Ping
author_facet Wang, Qian
Tian, Xuefei
Wang, Yuyang
Wang, Yan
Li, Jialin
Zhao, Tingting
Li, Ping
author_sort Wang, Qian
collection PubMed
description Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). Actin cytoskeleton rearrangement in podocyte induced by multiple pathogenic factors is believed to be the key process resulting in glomerular injury. Many studies have recently shown that transient receptor potential canonical channel 6 (TRPC6) in podocyte plays a critical role in the development and progression of proteinuric kidney disease by regulating its actin cytoskeleton rearrangement. This review is aimed at summarizing the role of TRPC6 on DKD by regulating the podocyte actin cytoskeleton rearrangement, thereby help further broaden our views and understanding on the mechanism of DKD and provide a theoretic basis for exploring new therapeutic targets for DKD patients.
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spelling pubmed-69647192020-01-29 Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement Wang, Qian Tian, Xuefei Wang, Yuyang Wang, Yan Li, Jialin Zhao, Tingting Li, Ping J Diabetes Res Review Article Podocyte injury is an important pathogenesis step causing proteinuric kidney diseases such as diabetic kidney disease (DKD). Actin cytoskeleton rearrangement in podocyte induced by multiple pathogenic factors is believed to be the key process resulting in glomerular injury. Many studies have recently shown that transient receptor potential canonical channel 6 (TRPC6) in podocyte plays a critical role in the development and progression of proteinuric kidney disease by regulating its actin cytoskeleton rearrangement. This review is aimed at summarizing the role of TRPC6 on DKD by regulating the podocyte actin cytoskeleton rearrangement, thereby help further broaden our views and understanding on the mechanism of DKD and provide a theoretic basis for exploring new therapeutic targets for DKD patients. Hindawi 2020-01-03 /pmc/articles/PMC6964719/ /pubmed/31998809 http://dx.doi.org/10.1155/2020/6897390 Text en Copyright © 2020 Qian Wang et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wang, Qian
Tian, Xuefei
Wang, Yuyang
Wang, Yan
Li, Jialin
Zhao, Tingting
Li, Ping
Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement
title Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement
title_full Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement
title_fullStr Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement
title_full_unstemmed Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement
title_short Role of Transient Receptor Potential Canonical Channel 6 (TRPC6) in Diabetic Kidney Disease by Regulating Podocyte Actin Cytoskeleton Rearrangement
title_sort role of transient receptor potential canonical channel 6 (trpc6) in diabetic kidney disease by regulating podocyte actin cytoskeleton rearrangement
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964719/
https://www.ncbi.nlm.nih.gov/pubmed/31998809
http://dx.doi.org/10.1155/2020/6897390
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