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Low dose ionizing radiation strongly stimulates insertional mutagenesis in a γH2AX dependent manner

Extrachromosomal DNA can integrate into the genome with no sequence specificity producing an insertional mutation. This process, which is referred to as random integration (RI), requires a double stranded break (DSB) in the genome. Inducing DSBs by various means, including ionizing radiation, increa...

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Detalles Bibliográficos
Autores principales:	Zelensky, Alex N., Schoonakker, Mascha, Brandsma, Inger, Tijsterman, Marcel, van Gent, Dik C., Essers, Jeroen, Kanaar, Roland
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964834/ https://www.ncbi.nlm.nih.gov/pubmed/31945059 http://dx.doi.org/10.1371/journal.pgen.1008550

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