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Administration of Interleukin-15 Peptide Improves Cardiac Function in a Mouse Model of Myocardial Infarction

Interleukin-15 is a pleotropic factor, capable of modulating metabolism, survival, proliferation, and differentiation in many different cell types. The rationale behind this study relates to previous work demonstrating that IL-15 is a major factor present in stem cell extracts, which protects cardio...

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Detalles Bibliográficos
Autores principales: Ameri, Kurosh, Bayardorj, Dulguun, Samurkashian, Raffi, Fredkin, Maxwell, Fuh, Eric, Nguyen, Vien, Yeghiazarians, Yerem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Journal of Cardiovascular Pharmacology 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6964872/
https://www.ncbi.nlm.nih.gov/pubmed/31815824
http://dx.doi.org/10.1097/FJC.0000000000000764
Descripción
Sumario:Interleukin-15 is a pleotropic factor, capable of modulating metabolism, survival, proliferation, and differentiation in many different cell types. The rationale behind this study relates to previous work demonstrating that IL-15 is a major factor present in stem cell extracts, which protects cardiomyocytes subjected to hypoxic stress in vitro. The objective of this current study was to assess whether administration of IL-15 peptide will also show protective effects in vivo. The data indicate that administration of IL-15 reduces cell death, increases vascularity, decreases scar size, and significantly improves left ventricular ejection fraction in a mouse model of myocardial infarction.