Multiple Dynamical Mechanisms of Phase-2 Early Afterdepolarizations in a Human Ventricular Myocyte Model: Involvement of Spontaneous SR Ca(2+) Release

Early afterdepolarization (EAD) is known to cause lethal ventricular arrhythmias in long QT syndrome (LQTS). In this study, dynamical mechanisms of EAD formation in human ventricular myocytes (HVMs) were investigated using the mathematical model developed by ten Tusscher and Panfilov (Am J Physiol H...

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Detalles Bibliográficos
Autores principales: Kurata, Yasutaka, Tsumoto, Kunichika, Hayashi, Kenshi, Hisatome, Ichiro, Kuda, Yuhichi, Tanida, Mamoru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965073/
https://www.ncbi.nlm.nih.gov/pubmed/31998140
http://dx.doi.org/10.3389/fphys.2019.01545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965073/
https://www.ncbi.nlm.nih.gov/pubmed/31998140
http://dx.doi.org/10.3389/fphys.2019.01545

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