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High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in t...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965090/ https://www.ncbi.nlm.nih.gov/pubmed/31949271 http://dx.doi.org/10.1038/s41598-019-57366-y |
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author | Choi, Seok-Jin Hong, Yoon-Ho Kim, Sung-Min Shin, Je-Young Suh, Young Ju Sung, Jung-Joon |
author_facet | Choi, Seok-Jin Hong, Yoon-Ho Kim, Sung-Min Shin, Je-Young Suh, Young Ju Sung, Jung-Joon |
author_sort | Choi, Seok-Jin |
collection | PubMed |
description | The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS. |
format | Online Article Text |
id | pubmed-6965090 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-69650902020-01-23 High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis Choi, Seok-Jin Hong, Yoon-Ho Kim, Sung-Min Shin, Je-Young Suh, Young Ju Sung, Jung-Joon Sci Rep Article The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS. Nature Publishing Group UK 2020-01-16 /pmc/articles/PMC6965090/ /pubmed/31949271 http://dx.doi.org/10.1038/s41598-019-57366-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Choi, Seok-Jin Hong, Yoon-Ho Kim, Sung-Min Shin, Je-Young Suh, Young Ju Sung, Jung-Joon High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis |
title | High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis |
title_full | High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis |
title_fullStr | High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis |
title_full_unstemmed | High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis |
title_short | High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis |
title_sort | high neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965090/ https://www.ncbi.nlm.nih.gov/pubmed/31949271 http://dx.doi.org/10.1038/s41598-019-57366-y |
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