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High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis

The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in t...

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Autores principales: Choi, Seok-Jin, Hong, Yoon-Ho, Kim, Sung-Min, Shin, Je-Young, Suh, Young Ju, Sung, Jung-Joon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965090/
https://www.ncbi.nlm.nih.gov/pubmed/31949271
http://dx.doi.org/10.1038/s41598-019-57366-y
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author Choi, Seok-Jin
Hong, Yoon-Ho
Kim, Sung-Min
Shin, Je-Young
Suh, Young Ju
Sung, Jung-Joon
author_facet Choi, Seok-Jin
Hong, Yoon-Ho
Kim, Sung-Min
Shin, Je-Young
Suh, Young Ju
Sung, Jung-Joon
author_sort Choi, Seok-Jin
collection PubMed
description The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS.
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spelling pubmed-69650902020-01-23 High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis Choi, Seok-Jin Hong, Yoon-Ho Kim, Sung-Min Shin, Je-Young Suh, Young Ju Sung, Jung-Joon Sci Rep Article The present study aimed to investigate the prognostic importance of the neutrophil-to-lymphocyte ratio (NLR) in patients with amyotrophic lateral sclerosis (ALS). Among 322 patients diagnosed as having definite, probable, or possible ALS at a single tertiary hospital, 194 patients were included in the final analysis. Patients were divided into three groups (T1, T2, and T3) according to the tertile of their NLR. Survival rate was significantly lower in T3 compared to the other groups (log-rank test; T1 vs. T3, p = 0.009; T2 vs. T3, p = 0.008). Median survival duration was 37.0 (24.0–56.0), 32.5 (19.5–51.2), and 22.0 (17.0–38.0) months in T1, T2, and T3, respectively. In a multivariable Cox proportional hazards regression analysis, the hazard ratio of age at onset, bulbar-onset, and NLR (T3/T1) was 1.04 (1.02–1.06, p < 0.001), 1.68 (1.10–2.57, p = 0.015), and 1.60 (1.01–2.51, p = 0.041), respectively. A high baseline NLR may serve as a useful indicator for short survival duration in patients with ALS. Nature Publishing Group UK 2020-01-16 /pmc/articles/PMC6965090/ /pubmed/31949271 http://dx.doi.org/10.1038/s41598-019-57366-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Choi, Seok-Jin
Hong, Yoon-Ho
Kim, Sung-Min
Shin, Je-Young
Suh, Young Ju
Sung, Jung-Joon
High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
title High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
title_full High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
title_fullStr High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
title_full_unstemmed High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
title_short High neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
title_sort high neutrophil-to-lymphocyte ratio predicts short survival duration in amyotrophic lateral sclerosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965090/
https://www.ncbi.nlm.nih.gov/pubmed/31949271
http://dx.doi.org/10.1038/s41598-019-57366-y
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