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Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS

Moderate to severe chronic graft-versus-host disease (cGVHD) is associated with high morbidity, hospital dependency and poor quality of life. In this study, we analyzed a well-defined consecutive series of 98 patients with acute myelogenous leukemia/myelodysplastic syndrome (AML/MDS) who received al...

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Autores principales: Kok, Laurence M. C., Bungener, Laura, de Bock, Geertruida H., Biswana, Anouschka, van der Wal, Geertiena, van Imhoff, Gustaaf W., Bellido, Mar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Japan 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965489/
https://www.ncbi.nlm.nih.gov/pubmed/31732859
http://dx.doi.org/10.1007/s13577-019-00297-7
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author Kok, Laurence M. C.
Bungener, Laura
de Bock, Geertruida H.
Biswana, Anouschka
van der Wal, Geertiena
van Imhoff, Gustaaf W.
Bellido, Mar
author_facet Kok, Laurence M. C.
Bungener, Laura
de Bock, Geertruida H.
Biswana, Anouschka
van der Wal, Geertiena
van Imhoff, Gustaaf W.
Bellido, Mar
author_sort Kok, Laurence M. C.
collection PubMed
description Moderate to severe chronic graft-versus-host disease (cGVHD) is associated with high morbidity, hospital dependency and poor quality of life. In this study, we analyzed a well-defined consecutive series of 98 patients with acute myelogenous leukemia/myelodysplastic syndrome (AML/MDS) who received allogeneic stem cell transplantation with non-myeloablative (NMA) conditioning to determine risk factors associated with the severity of cGVHD. cGVHD was defined according to the 2005 National Institute of Health consensus criteria. Transfusions before transplantation, presence of HLA antibodies, composition of the graft (CD3+, CD19+, CD34+ cells), sibling or matched unrelated donor, female donor to male recipient, CMV serology and the development of acute GVHD (aGVHD), were considered potential risk factors. Multivariate Cox regression analysis identified the number of CD19+ 10(6)/kg (HR 2.79; 95% CI 1.35–5.74), CD3+ 10(6)/kg (HR 2.18; 95% CI 1.04–4.59) infused cells and the presence of patient HLA antibodies before transplantation (HR 2.34; CI 1.11–4.95) as significant risk factors for the development of moderate to severe cGVHD. In summary, we identified in a small, but well-defined cohort, 3 risk factors associated with the severity of cGVHD that should be validated in a larger multi-center study. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13577-019-00297-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-69654892020-01-30 Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS Kok, Laurence M. C. Bungener, Laura de Bock, Geertruida H. Biswana, Anouschka van der Wal, Geertiena van Imhoff, Gustaaf W. Bellido, Mar Hum Cell Research Article Moderate to severe chronic graft-versus-host disease (cGVHD) is associated with high morbidity, hospital dependency and poor quality of life. In this study, we analyzed a well-defined consecutive series of 98 patients with acute myelogenous leukemia/myelodysplastic syndrome (AML/MDS) who received allogeneic stem cell transplantation with non-myeloablative (NMA) conditioning to determine risk factors associated with the severity of cGVHD. cGVHD was defined according to the 2005 National Institute of Health consensus criteria. Transfusions before transplantation, presence of HLA antibodies, composition of the graft (CD3+, CD19+, CD34+ cells), sibling or matched unrelated donor, female donor to male recipient, CMV serology and the development of acute GVHD (aGVHD), were considered potential risk factors. Multivariate Cox regression analysis identified the number of CD19+ 10(6)/kg (HR 2.79; 95% CI 1.35–5.74), CD3+ 10(6)/kg (HR 2.18; 95% CI 1.04–4.59) infused cells and the presence of patient HLA antibodies before transplantation (HR 2.34; CI 1.11–4.95) as significant risk factors for the development of moderate to severe cGVHD. In summary, we identified in a small, but well-defined cohort, 3 risk factors associated with the severity of cGVHD that should be validated in a larger multi-center study. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s13577-019-00297-7) contains supplementary material, which is available to authorized users. Springer Japan 2019-11-15 2020 /pmc/articles/PMC6965489/ /pubmed/31732859 http://dx.doi.org/10.1007/s13577-019-00297-7 Text en © The Author(s) 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Research Article
Kok, Laurence M. C.
Bungener, Laura
de Bock, Geertruida H.
Biswana, Anouschka
van der Wal, Geertiena
van Imhoff, Gustaaf W.
Bellido, Mar
Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS
title Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS
title_full Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS
title_fullStr Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS
title_full_unstemmed Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS
title_short Risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with AML or MDS
title_sort risk factors associated with the development of moderate to severe chronic graft-versus-host disease after non-myeloablative conditioning allogeneic stem cell transplantation in patients with aml or mds
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965489/
https://www.ncbi.nlm.nih.gov/pubmed/31732859
http://dx.doi.org/10.1007/s13577-019-00297-7
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