The nuclear translocation of transketolase inhibits the farnesoid receptor expression by promoting the binding of HDAC3 to FXR promoter in hepatocellular carcinoma cell lines

Transketolase (TKT), which is a metabolic enzyme in the nonoxidative phase of the pentose phosphate pathway (PPP), plays an important role in providing cancer cells with raw materials for macromolecular biosynthesis. The ectopic expression of TKT in hepatocellular carcinoma (HCC) was reported previo...

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Detalles Bibliográficos
Autores principales: Li, Minle, Zhang, Xuping, Lu, Ying, Meng, Sen, Quan, Haoyu, Hou, Pingfu, Tong, Pan, Chai, Dafei, Gao, Xiaoge, Zheng, Junnian, Tong, Xuemei, Bai, Jin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965636/
https://www.ncbi.nlm.nih.gov/pubmed/31949131
http://dx.doi.org/10.1038/s41419-020-2225-6

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