Characterization of binding, functional activity, and contractile responses of the selective 5‐HT(1F) receptor agonist lasmiditan

BACKGROUND AND PURPOSE: Triptans are 5‐HT(1B/1D) receptor agonists (that also display 5‐HT(1F) receptor affinity) with antimigraine action, contraindicated in patients with coronary artery disease due to their vasoconstrictor properties. Conversely, lasmiditan was developed as an antimigraine 5‐HT(1...

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Detalles Bibliográficos
Autores principales: Rubio‐Beltrán, Eloísa, Labastida‐Ramírez, Alejandro, Haanes, Kristian A., van den Bogaerdt, Antoon, Bogers, Ad J.J.C., Zanelli, Eric, Meeus, Laurent, Danser, A.H. Jan, Gralinski, Michael R., Senese, Peter B., Johnson, Kirk W., Kovalchin, Joseph, Villalón, Carlos M., MaassenVanDenBrink, Antoinette
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965684/
https://www.ncbi.nlm.nih.gov/pubmed/31418454
http://dx.doi.org/10.1111/bph.14832

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