Computational evolution of an RNA-binding protein towards enhanced oxidized-RNA binding

The oxidation of RNA has been implicated in the development of many diseases. Among the four ribonucleotides, guanosine is the most susceptible to oxidation, resulting in the formation of 8-oxo-7,8-dihydroguanosine (8-oxoG). Despite the limited knowledge about how cells regulate the detrimental effe...

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Detalles Bibliográficos
Autores principales: Gonzalez-Rivera, Juan C., Orr, Asuka A., Engels, Sean M., Jakubowski, Joseph M., Sherman, Mark W., O'Connor, Katherine N., Matteson, Tomas, Woodcock, Brendan C., Contreras, Lydia M., Tamamis, Phanourios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Research Network of Computational and Structural Biotechnology 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6965710/
https://www.ncbi.nlm.nih.gov/pubmed/31988703
http://dx.doi.org/10.1016/j.csbj.2019.12.003

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