Cargando…
Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action
Alzheimer's disease (AD) is the most common form of dementia and has become a growing health concern in aging societies. β-amyloid (Aβ) formation in vulnerable brain regions, such as the hippocampus and cerebral cortex is a major neuropathological feature of the disease. Currently, there is no...
Autor principal: | |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966106/ https://www.ncbi.nlm.nih.gov/pubmed/32010339 http://dx.doi.org/10.3892/etm.2019.8390 |
_version_ | 1783488678950076416 |
---|---|
author | Sripanidkulchai, Bungorn |
author_facet | Sripanidkulchai, Bungorn |
author_sort | Sripanidkulchai, Bungorn |
collection | PubMed |
description | Alzheimer's disease (AD) is the most common form of dementia and has become a growing health concern in aging societies. β-amyloid (Aβ) formation in vulnerable brain regions, such as the hippocampus and cerebral cortex is a major neuropathological feature of the disease. Currently, there is no specific drug available for the treatment of AD. However, due to its high antioxidant activity, aged garlic extract (AGE) has been widely used to prevent chronic diseases, such as cancer and cardiovascular disease. A number of studies on the benefits of AGE against cognitive and memory deficits have also been published. This review aimed to summarize the information related to the effects of AGE on learning memory in order to obtain a better understanding of its mechanisms of action. This review also presents an overview of the pathogenesis of AD, and summarizes the main ingredients and neuroprotective effects of AGE against cognitive and learning memory deficits. The mechanisms of action of AGE are also discussed. |
format | Online Article Text |
id | pubmed-6966106 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-69661062020-01-31 Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action Sripanidkulchai, Bungorn Exp Ther Med Review Alzheimer's disease (AD) is the most common form of dementia and has become a growing health concern in aging societies. β-amyloid (Aβ) formation in vulnerable brain regions, such as the hippocampus and cerebral cortex is a major neuropathological feature of the disease. Currently, there is no specific drug available for the treatment of AD. However, due to its high antioxidant activity, aged garlic extract (AGE) has been widely used to prevent chronic diseases, such as cancer and cardiovascular disease. A number of studies on the benefits of AGE against cognitive and memory deficits have also been published. This review aimed to summarize the information related to the effects of AGE on learning memory in order to obtain a better understanding of its mechanisms of action. This review also presents an overview of the pathogenesis of AD, and summarizes the main ingredients and neuroprotective effects of AGE against cognitive and learning memory deficits. The mechanisms of action of AGE are also discussed. D.A. Spandidos 2020-02 2019-12-27 /pmc/articles/PMC6966106/ /pubmed/32010339 http://dx.doi.org/10.3892/etm.2019.8390 Text en Copyright: © Sripanidkulchai et al. This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Sripanidkulchai, Bungorn Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action |
title | Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action |
title_full | Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action |
title_fullStr | Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action |
title_full_unstemmed | Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action |
title_short | Benefits of aged garlic extract on Alzheimer's disease: Possible mechanisms of action |
title_sort | benefits of aged garlic extract on alzheimer's disease: possible mechanisms of action |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966106/ https://www.ncbi.nlm.nih.gov/pubmed/32010339 http://dx.doi.org/10.3892/etm.2019.8390 |
work_keys_str_mv | AT sripanidkulchaibungorn benefitsofagedgarlicextractonalzheimersdiseasepossiblemechanismsofaction |