Probenecid‐Boosted Tenofovir: A Physiologically‐Based Pharmacokinetic Model‐Informed Strategy for On‐Demand HIV Preexposure Prophylaxis

Multiple doses of tenofovir disoproxil fumarate (TDF) together with emtricitabine is effective for HIV preexposure prophylaxis (PrEP). TDF is converted to tenofovir (TFV) in circulation, which is subsequently cleared via tubular secretion by organic ion transporters (OATs; OAT1 and OAT3). Using in v...

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Detalles Bibliográficos
Autores principales: Liu, Stephanie N., Desta, Zeruesenay, Gufford, Brandon T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2019
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966182/
https://www.ncbi.nlm.nih.gov/pubmed/31749296
http://dx.doi.org/10.1002/psp4.12481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966182/
https://www.ncbi.nlm.nih.gov/pubmed/31749296
http://dx.doi.org/10.1002/psp4.12481

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