Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome

In a case–control study of patients with Clostridium difficile infection, we found no statistically significant association between the presence of trehalose utilization variants in infecting C. difficile strains and development of severe infection outcome. These results do not support trehalose uti...

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Autores principales: Saund, Katie, Rao, Krishna, Young, Vincent B, Snitkin, Evan S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966243/
https://www.ncbi.nlm.nih.gov/pubmed/31976356
http://dx.doi.org/10.1093/ofid/ofz548
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author Saund, Katie
Rao, Krishna
Young, Vincent B
Snitkin, Evan S
author_facet Saund, Katie
Rao, Krishna
Young, Vincent B
Snitkin, Evan S
author_sort Saund, Katie
collection PubMed
description In a case–control study of patients with Clostridium difficile infection, we found no statistically significant association between the presence of trehalose utilization variants in infecting C. difficile strains and development of severe infection outcome. These results do not support trehalose utilization conferring enhanced virulence in the context of human C. difficile infections.
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spelling pubmed-69662432020-01-23 Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome Saund, Katie Rao, Krishna Young, Vincent B Snitkin, Evan S Open Forum Infect Dis Brief Report In a case–control study of patients with Clostridium difficile infection, we found no statistically significant association between the presence of trehalose utilization variants in infecting C. difficile strains and development of severe infection outcome. These results do not support trehalose utilization conferring enhanced virulence in the context of human C. difficile infections. Oxford University Press 2020-01-04 /pmc/articles/PMC6966243/ /pubmed/31976356 http://dx.doi.org/10.1093/ofid/ofz548 Text en © The Author(s) 2020. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Saund, Katie
Rao, Krishna
Young, Vincent B
Snitkin, Evan S
Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome
title Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome
title_full Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome
title_fullStr Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome
title_full_unstemmed Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome
title_short Genetic Determinants of Trehalose Utilization Are Not Associated With Severe Clostridium difficile Infection Outcome
title_sort genetic determinants of trehalose utilization are not associated with severe clostridium difficile infection outcome
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966243/
https://www.ncbi.nlm.nih.gov/pubmed/31976356
http://dx.doi.org/10.1093/ofid/ofz548
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