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Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review
Breast cancers include a heterogeneous group of diseases with clinical behaviors that may vary according to the hormonal receptor status. However, limited knowledge is available on the role of breast cancer environmental and occupational risk factors in the onset of specific molecular disease phenot...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966433/ https://www.ncbi.nlm.nih.gov/pubmed/31783577 http://dx.doi.org/10.3390/cancers11121882 |
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author | Leso, Veruscka Ercolano, Maria Luigia Cioffi, Dante Luigi Iavicoli, Ivo |
author_facet | Leso, Veruscka Ercolano, Maria Luigia Cioffi, Dante Luigi Iavicoli, Ivo |
author_sort | Leso, Veruscka |
collection | PubMed |
description | Breast cancers include a heterogeneous group of diseases with clinical behaviors that may vary according to the hormonal receptor status. However, limited knowledge is available on the role of breast cancer environmental and occupational risk factors in the onset of specific molecular disease phenotypes. Therefore, the aim of this review was to provide an overview on the possible correlation between occupational chemical exposures and breast cancers with a specific receptor pattern. Pubmed, Scopus, and ISI Web of Science databases were systematically reviewed to identify all the studies addressing chemical exposure in workplaces and risk of breast cancer classified according to the presence of estrogen and/or progesterone receptors. Some positive associations were reported between solvent, polycyclic aromatic hydrocarbon, organophosphoric insecticide, and synthetic fiber exposure and estrogen receptor-positive cases, while other investigations demonstrated a relationship with receptor-negative tumors or failed to detect any significant effect. Overall, further investigation should overcome limitations due to the self-reported information on work histories, the chemical classification in general categories, and the lack of environmental or biological monitoring exposure data. This may support the development of suitable and individually “tailored” occupational risk assessment and management strategies to protect the health of exposed workers, particularly those with hypersusceptibility conditions. |
format | Online Article Text |
id | pubmed-6966433 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-69664332020-01-27 Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review Leso, Veruscka Ercolano, Maria Luigia Cioffi, Dante Luigi Iavicoli, Ivo Cancers (Basel) Review Breast cancers include a heterogeneous group of diseases with clinical behaviors that may vary according to the hormonal receptor status. However, limited knowledge is available on the role of breast cancer environmental and occupational risk factors in the onset of specific molecular disease phenotypes. Therefore, the aim of this review was to provide an overview on the possible correlation between occupational chemical exposures and breast cancers with a specific receptor pattern. Pubmed, Scopus, and ISI Web of Science databases were systematically reviewed to identify all the studies addressing chemical exposure in workplaces and risk of breast cancer classified according to the presence of estrogen and/or progesterone receptors. Some positive associations were reported between solvent, polycyclic aromatic hydrocarbon, organophosphoric insecticide, and synthetic fiber exposure and estrogen receptor-positive cases, while other investigations demonstrated a relationship with receptor-negative tumors or failed to detect any significant effect. Overall, further investigation should overcome limitations due to the self-reported information on work histories, the chemical classification in general categories, and the lack of environmental or biological monitoring exposure data. This may support the development of suitable and individually “tailored” occupational risk assessment and management strategies to protect the health of exposed workers, particularly those with hypersusceptibility conditions. MDPI 2019-11-27 /pmc/articles/PMC6966433/ /pubmed/31783577 http://dx.doi.org/10.3390/cancers11121882 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Leso, Veruscka Ercolano, Maria Luigia Cioffi, Dante Luigi Iavicoli, Ivo Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review |
title | Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review |
title_full | Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review |
title_fullStr | Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review |
title_full_unstemmed | Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review |
title_short | Occupational Chemical Exposure and Breast Cancer Risk According to Hormone Receptor Status: A Systematic Review |
title_sort | occupational chemical exposure and breast cancer risk according to hormone receptor status: a systematic review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966433/ https://www.ncbi.nlm.nih.gov/pubmed/31783577 http://dx.doi.org/10.3390/cancers11121882 |
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