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Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia

Coronary Artery Ectasia (CAE) is a phenomenon characterized by locally or diffuse coronary artery dilation of one or more coronary arteries. In the present study, the prevalence of acquired coronary ectasia and coronary risk factors for CAE was analyzed in patients undergoing cardiac catheterization...

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Autores principales: Jafari, Jamal, Daum, Aner, Hamed, Jihad Abu, Osherov, Azriel, Orlov, Yan, Yosefy, Chaim, Gallego-Colon, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966440/
https://www.ncbi.nlm.nih.gov/pubmed/31591337
http://dx.doi.org/10.3390/biomedicines7040079
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author Jafari, Jamal
Daum, Aner
Hamed, Jihad Abu
Osherov, Azriel
Orlov, Yan
Yosefy, Chaim
Gallego-Colon, Enrique
author_facet Jafari, Jamal
Daum, Aner
Hamed, Jihad Abu
Osherov, Azriel
Orlov, Yan
Yosefy, Chaim
Gallego-Colon, Enrique
author_sort Jafari, Jamal
collection PubMed
description Coronary Artery Ectasia (CAE) is a phenomenon characterized by locally or diffuse coronary artery dilation of one or more coronary arteries. In the present study, the prevalence of acquired coronary ectasia and coronary risk factors for CAE was analyzed in patients undergoing cardiac catheterization for suspected ischemic heart disease. We retrospectively analyzed 4000 patients undergoing coronary angiography for suspected coronary artery disease at our cardiac catheterization unit, and a total of 171 patients were selected. The study group was divided into three groups, 65 patients with CAE, 62 patients with significant obstructive coronary artery disease, and 44 patients with normal coronary angiograms as a control group. A negative correlation was observed between high-density lipoprotein cholesterol (HDL-C) and the presence of CAE (r = −0.274, p < 0.001). In addition, HDL-C (OR, 0.858; CI, 0.749–0.984; p = 0.029), low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio (OR, 1.987; CI, 1.542–2.882; p = 0.034), and hemoglobin (OR, 2.060; CI, 1.114–3.809; p = 0.021) were identified as independent risk factors for the development of CAE. In fact, we observed that a one-unit increase in HDL-C corresponded to a 15% risk reduction in CAE development and that each unit increase in hemoglobin could potentially increase the CAE risk by 2-fold. Low HDL-C could significantly increase the risk of developing CAE in healthy individuals. Elevated hemoglobin could predispose to subsequent dilation and aneurysm of the coronary artery. This work suggests that disordered lipoprotein metabolism or altered hemoglobin values can predispose patients to aneurysmal coronary artery disease.
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spelling pubmed-69664402020-01-27 Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia Jafari, Jamal Daum, Aner Hamed, Jihad Abu Osherov, Azriel Orlov, Yan Yosefy, Chaim Gallego-Colon, Enrique Biomedicines Article Coronary Artery Ectasia (CAE) is a phenomenon characterized by locally or diffuse coronary artery dilation of one or more coronary arteries. In the present study, the prevalence of acquired coronary ectasia and coronary risk factors for CAE was analyzed in patients undergoing cardiac catheterization for suspected ischemic heart disease. We retrospectively analyzed 4000 patients undergoing coronary angiography for suspected coronary artery disease at our cardiac catheterization unit, and a total of 171 patients were selected. The study group was divided into three groups, 65 patients with CAE, 62 patients with significant obstructive coronary artery disease, and 44 patients with normal coronary angiograms as a control group. A negative correlation was observed between high-density lipoprotein cholesterol (HDL-C) and the presence of CAE (r = −0.274, p < 0.001). In addition, HDL-C (OR, 0.858; CI, 0.749–0.984; p = 0.029), low-density lipoprotein cholesterol (LDL-C)/HDL-C ratio (OR, 1.987; CI, 1.542–2.882; p = 0.034), and hemoglobin (OR, 2.060; CI, 1.114–3.809; p = 0.021) were identified as independent risk factors for the development of CAE. In fact, we observed that a one-unit increase in HDL-C corresponded to a 15% risk reduction in CAE development and that each unit increase in hemoglobin could potentially increase the CAE risk by 2-fold. Low HDL-C could significantly increase the risk of developing CAE in healthy individuals. Elevated hemoglobin could predispose to subsequent dilation and aneurysm of the coronary artery. This work suggests that disordered lipoprotein metabolism or altered hemoglobin values can predispose patients to aneurysmal coronary artery disease. MDPI 2019-10-07 /pmc/articles/PMC6966440/ /pubmed/31591337 http://dx.doi.org/10.3390/biomedicines7040079 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Jafari, Jamal
Daum, Aner
Hamed, Jihad Abu
Osherov, Azriel
Orlov, Yan
Yosefy, Chaim
Gallego-Colon, Enrique
Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia
title Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia
title_full Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia
title_fullStr Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia
title_full_unstemmed Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia
title_short Low High-Density Lipoprotein Cholesterol Predisposes to Coronary Artery Ectasia
title_sort low high-density lipoprotein cholesterol predisposes to coronary artery ectasia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966440/
https://www.ncbi.nlm.nih.gov/pubmed/31591337
http://dx.doi.org/10.3390/biomedicines7040079
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