A Novel Inhibitor of STAT5 Signaling Overcomes Chemotherapy Resistance in Myeloid Leukemia Cells

Signal transducers and activators of transcription 5A and 5B (STAT5A and STAT5B) are crucial downstream effectors of tyrosine kinase oncogenes (TKO) such as BCR-ABL in chronic myeloid leukemia (CML) and FLT3-ITD in acute myeloid leukemia (AML). Both proteins have been shown to promote the resistance...

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Detalles Bibliográficos
Autores principales: Brachet-Botineau, Marie, Deynoux, Margaux, Vallet, Nicolas, Polomski, Marion, Juen, Ludovic, Hérault, Olivier, Mazurier, Frédéric, Viaud-Massuard, Marie-Claude, Prié, Gildas, Gouilleux, Fabrice
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966442/
https://www.ncbi.nlm.nih.gov/pubmed/31861239
http://dx.doi.org/10.3390/cancers11122043

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966442/
https://www.ncbi.nlm.nih.gov/pubmed/31861239
http://dx.doi.org/10.3390/cancers11122043

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