The Roles of Sirtuin Family Proteins in Cancer Progression

Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or deacylase activity and are linked to various cancer-related biological pathways as regulators of transcriptional progression. Sirtuins play fundamental roles in carcinogenesis and maintenance of the malignant phenotype...

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Autores principales: Zhao, Erhu, Hou, Jianbing, Ke, Xiaoxue, Abbas, Muhammad Nadeem, Kausar, Saima, Zhang, Lei, Cui, Hongjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966446/
https://www.ncbi.nlm.nih.gov/pubmed/31817470
http://dx.doi.org/10.3390/cancers11121949
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author Zhao, Erhu
Hou, Jianbing
Ke, Xiaoxue
Abbas, Muhammad Nadeem
Kausar, Saima
Zhang, Lei
Cui, Hongjuan
author_facet Zhao, Erhu
Hou, Jianbing
Ke, Xiaoxue
Abbas, Muhammad Nadeem
Kausar, Saima
Zhang, Lei
Cui, Hongjuan
author_sort Zhao, Erhu
collection PubMed
description Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or deacylase activity and are linked to various cancer-related biological pathways as regulators of transcriptional progression. Sirtuins play fundamental roles in carcinogenesis and maintenance of the malignant phenotype, mainly participating in cancer cell viability, apoptosis, metastasis, and tumorigenesis. Although sirtuin family members have a high degree of homology, they may play different roles in various kinds of cancer. This review highlights their fundamental roles in tumorigenesis and cancer development and provides a critical discussion of their dual roles in cancer, namely, as tumor promoters or tumor suppressors.
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spelling pubmed-69664462020-01-27 The Roles of Sirtuin Family Proteins in Cancer Progression Zhao, Erhu Hou, Jianbing Ke, Xiaoxue Abbas, Muhammad Nadeem Kausar, Saima Zhang, Lei Cui, Hongjuan Cancers (Basel) Review Sirtuin family members are characterized by either mono-ADP-ribosyltransferase or deacylase activity and are linked to various cancer-related biological pathways as regulators of transcriptional progression. Sirtuins play fundamental roles in carcinogenesis and maintenance of the malignant phenotype, mainly participating in cancer cell viability, apoptosis, metastasis, and tumorigenesis. Although sirtuin family members have a high degree of homology, they may play different roles in various kinds of cancer. This review highlights their fundamental roles in tumorigenesis and cancer development and provides a critical discussion of their dual roles in cancer, namely, as tumor promoters or tumor suppressors. MDPI 2019-12-05 /pmc/articles/PMC6966446/ /pubmed/31817470 http://dx.doi.org/10.3390/cancers11121949 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Zhao, Erhu
Hou, Jianbing
Ke, Xiaoxue
Abbas, Muhammad Nadeem
Kausar, Saima
Zhang, Lei
Cui, Hongjuan
The Roles of Sirtuin Family Proteins in Cancer Progression
title The Roles of Sirtuin Family Proteins in Cancer Progression
title_full The Roles of Sirtuin Family Proteins in Cancer Progression
title_fullStr The Roles of Sirtuin Family Proteins in Cancer Progression
title_full_unstemmed The Roles of Sirtuin Family Proteins in Cancer Progression
title_short The Roles of Sirtuin Family Proteins in Cancer Progression
title_sort roles of sirtuin family proteins in cancer progression
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966446/
https://www.ncbi.nlm.nih.gov/pubmed/31817470
http://dx.doi.org/10.3390/cancers11121949
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