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Overactivation of Akt Contributes to MEK Inhibitor Primary and Acquired Resistance in Colorectal Cancer Cells

RAS and BRAF-mutated colorectal cancers are associated with resistance to chemotherapy and poor prognosis, highlighting the need for new therapeutic strategies. Although these cancers sometimes respond to mitogen activated protein kinase kinase (MEK) inhibitor treatment, they often acquire resistanc...

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Detalles Bibliográficos
Autores principales:	Tsubaki, Masanobu, Takeda, Tomoya, Noguchi, Masaki, Jinushi, Minami, Seki, Shiori, Morii, Yuusuke, Shimomura, Kazunori, Imano, Motohiro, Satou, Takao, Nishida, Shozo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966459/ https://www.ncbi.nlm.nih.gov/pubmed/31769426 http://dx.doi.org/10.3390/cancers11121866

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