Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model

The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor–host interactions and for gene...

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Detalles Bibliográficos
Autores principales: De Giovanni, Carla, Nicoletti, Giordano, Landuzzi, Lorena, Palladini, Arianna, Lollini, Pier-Luigi, Nanni, Patrizia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966465/
https://www.ncbi.nlm.nih.gov/pubmed/31783695
http://dx.doi.org/10.3390/cancers11121889
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author De Giovanni, Carla
Nicoletti, Giordano
Landuzzi, Lorena
Palladini, Arianna
Lollini, Pier-Luigi
Nanni, Patrizia
author_facet De Giovanni, Carla
Nicoletti, Giordano
Landuzzi, Lorena
Palladini, Arianna
Lollini, Pier-Luigi
Nanni, Patrizia
author_sort De Giovanni, Carla
collection PubMed
description The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor–host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer.
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spelling pubmed-69664652020-01-27 Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model De Giovanni, Carla Nicoletti, Giordano Landuzzi, Lorena Palladini, Arianna Lollini, Pier-Luigi Nanni, Patrizia Cancers (Basel) Review The TS/A cell line was established in 1983 from a spontaneous mammary tumor arisen in an inbred BALB/c female mouse. Its features (heterogeneity, low immunogenicity and metastatic ability) rendered the TS/A cell line suitable as a preclinical model for studies on tumor–host interactions and for gene therapy approaches. The integrated biological profile of TS/A resulting from the review of the literature could be a path towards the description of a precision experimental model of mammary cancer. MDPI 2019-11-27 /pmc/articles/PMC6966465/ /pubmed/31783695 http://dx.doi.org/10.3390/cancers11121889 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
De Giovanni, Carla
Nicoletti, Giordano
Landuzzi, Lorena
Palladini, Arianna
Lollini, Pier-Luigi
Nanni, Patrizia
Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model
title Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model
title_full Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model
title_fullStr Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model
title_full_unstemmed Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model
title_short Bioprofiling TS/A Murine Mammary Cancer for a Functional Precision Experimental Model
title_sort bioprofiling ts/a murine mammary cancer for a functional precision experimental model
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966465/
https://www.ncbi.nlm.nih.gov/pubmed/31783695
http://dx.doi.org/10.3390/cancers11121889
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