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Pathways, Processes, and Candidate Drugs Associated with a Hoxa Cluster-Dependency Model of Leukemia
High expression of the HOXA cluster correlates with poor clinical outcome in acute myeloid leukemias, particularly those harboring rearrangements of the mixed-lineage-leukemia gene (MLLr). Whilst decreased HOXA expression acts as a readout for candidate experimental therapies, the necessity of the H...
Autores principales: | Kettyle, Laura M., Lebert-Ghali, Charles-Étienne, Grishagin, Ivan V., Dickson, Glenda J., O’Reilly, Paul G., Simpson, David A., Bijl, Janet J., Mills, Ken I., Sauvageau, Guy, Thompson, Alexander |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6966468/ https://www.ncbi.nlm.nih.gov/pubmed/31861091 http://dx.doi.org/10.3390/cancers11122036 |
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